CAJ | 학술논문

目的：探讨西酞普兰片联合银杏叶胶囊治疗脑梗死后抑郁的临床疗效。方法48例脑梗死后抑郁患者随机分为对照组(24例)和治疗组(24例)，在常规治疗的基础上，对照组给予氢溴酸西酞普兰片治疗，治疗组予氢溴酸西酞普兰片和银杏叶胶囊治疗，两组疗程均为8周。分别于治疗前和治疗后8周以汉密尔顿抑郁量表(HAMD)、美国国立卫生研究院卒中量表(NIHSS)评定症状的严重程度，以HAMD减分率评定疗效。结果治疗组疗效优于对照组(P<0.05)；治疗后两组间HAMD、NIHSS评分差异有统计学意义(P<0.05)。其中1例患者出现一过性不良反应：头晕和失眠。结论西酞普兰片联合银杏叶胶囊治疗脑梗死后抑郁疗效显著，患者神经功能恢复明显，且不良反应少。
목적：탐토서태보란편연합은행협효낭치료뇌경사후억욱적림상료효。방법48례뇌경사후억욱환자수궤분위대조조(24례)화치료조(24례)，재상규치료적기출상，대조조급여경추산서태보란편치료，치료조여경추산서태보란편화은행협효낭치료，량조료정균위8주。분별우치료전화치료후8주이한밀이돈억욱량표(HAMD)、미국국립위생연구원졸중량표(NIHSS)평정증상적엄중정도，이HAMD감분솔평정료효。결과치료조료효우우대조조(P<0.05)；치료후량조간HAMD、NIHSS평분차이유통계학의의(P<0.05)。기중1례환자출현일과성불량반응：두훈화실면。결론서태보란편연합은행협효낭치료뇌경사후억욱료효현저，환자신경공능회복명현，차불량반응소。
Objective To investigate the clinical effect of citalopram tablets combined with ginkgo leaf capsules in the treatment of depression after cerebral infarction. Methods A total of 48 cases of cerebral infarction were randomly divided into control group (n=24) and treatment group (n=24). On the basis of conventional treatment, the control group received citalopram hydrobromide tablets, and the treatment group received citalopram hydrobromide tablets combined with ginkgo leaf capsules. The treatment lasted for 8 weeks. Hamilton depression scale (HAMD) and national institute of health stroke scale (NIHSS) were applied to assess the severity of symptoms before the treatment and after 8 weeks of treatment. HAMD deduction rare was used to evaluate the curative effect. Results The curative effect of the treatment group was better than that of the control group (P<0.05). The differences of HAMD and NIHSS scores between the two groups had statistical significance (P<0.05). There was 1 case with transient adverse reaction as dizziness and ahypnosis. Conclusion Citalopram tablets combined with ginkgo leaf capsules in the treatment of depression after cerebral infarction has significant effect and few adverse reaction, it can also enhance neural function recovery.