CAJ | 학술논문

目的：探讨2型糖尿病(T2DM)及其继发的脂毒性在临床上具有扩张型心肌病(DCM)特点的心肌病变分布及其对患者心功能的影响。方法具有扩张型心肌病变特点患者共259例，分析其T2DM患病情况及血清游离脂肪酸(FFA)水平，了解T2DM及FFA对DCM患者心功能的影响。结果 DCM患者，特别是继发性者，具有较高的T2DM患病率，合并T2DM及高FFA水平的DCM患者心功能较差。结论 DCM患者具有较高的T2DM患病率及其继发的脂毒性，临床工作中应引起重视。
목적：탐토2형당뇨병(T2DM)급기계발적지독성재림상상구유확장형심기병(DCM)특점적심기병변분포급기대환자심공능적영향。방법구유확장형심기병변특점환자공259례，분석기T2DM환병정황급혈청유리지방산(FFA)수평，료해T2DM급FFA대DCM환자심공능적영향。결과 DCM환자，특별시계발성자，구유교고적T2DM환병솔，합병T2DM급고FFA수평적DCM환자심공능교차。결론 DCM환자구유교고적T2DM환병솔급기계발적지독성，림상공작중응인기중시。
Objective To investigate the distribution of type 2 diabetes mellitus (T2DM), myocardial lesions with features of dilated cardiomyopathy (DCM) and secondary lipotoxicity, and the influence on patients’ cardiac function. Methods A total of 259 patients with DCM were enrolled. Their T2DM situation and serum free fatty acid (FFA) level were analyzed, so as to get to know the influence of T2DM and FFA on patients with DCM. Results Incidence of T2DM was high in patients with DCM, especially in those with secondary DCM. The cardiac function of DCM patients with T2DM combined with high levels of FFA was poor. Conclusion The morbidity of T2DM and its secondary lipotoxicity are high in patients with DCM, and it should be serious considered in clinical work.