CAJ | 학술논문

胸腺基质淋巴细胞生成素(TSLP)是一种类IL-7样的细胞因子.近年来研究发现,TSLP广泛表达于多种组织细胞,以参与Th2,Th1,Th17,Treg等多种免疫反应的方式,在呼吸系统疾病,皮肤黏膜免疫,胃肠道疾病,癌症,感染以及心血管系统疾病等多种免疫相关性疾病的进展过程中发挥重要作用.对TSLP致病作用及其机制研究,有助于深入理解免疫相关性疾病的致病机制,为临床防治提供新的思路.
흉선기질림파세포생성소(TSLP)시일충류IL-7양적세포인자.근년래연구발현,TSLP엄범표체우다충조직세포,이삼여Th2,Th1,Th17,Treg등다충면역반응적방식,재호흡계통질병,피부점막면역,위장도질병,암증,감염이급심혈관계통질병등다충면역상관성질병적진전과정중발휘중요작용.대TSLP치병작용급기궤제연구,유조우심입리해면역상관성질병적치병궤제,위림상방치제공신적사로.
Thymic stromal lymphopoietin (TSLP) is a novel IL-7-like cytokine originally identified in thymic stromal cell line supernatants.Recently study has shown that various cell types such as epithelial cells,epidermal keratinocytes and airway smooth muscle cells,also express TSLP.Not only does TSLP function to drive Th2 mediated inflammation,it also haves impacts on Th1/Th17 immune responses and Treg cell responses.Numerous studies now implicate TSLP in a growing number of different immue-related diseases including respiratory diseases,mucocutaneous immunity,intestinal inflammation,cancer,infection and cardiovascular diseases.Knowledge of TSLP in different disease states will be very important in furthering our comprehension of the pathophysiology of immue-related diseases and manipulating these diseases.