CAJ | 학술논문

肝脏疾病是危害人类健康的重要疾病之一，合适的小动物模型的缺乏在很大程度上制约了肝脏疾病的相关研究。人源化小鼠作为重要动物模型之一，在肝脏疾病的研究中有巨大的应用价值。本文对早期的uPA小鼠、FAH小鼠、TK-NOG小鼠和近年来的AFC8小鼠等几种应用较为广泛且有代表性的人源化小鼠模型及其在肝脏疾病研究中的应用进行了对比分析，阐述了它们各自的模型原理和优缺点，以期对人源化小鼠应用于人类肝脏疾病的研究具有较为直观的认识。
간장질병시위해인류건강적중요질병지일，합괄적소동물모형적결핍재흔대정도상제약료간장질병적상관연구。인원화소서작위중요동물모형지일，재간장질병적연구중유거대적응용개치。본문대조기적uPA소서、FAH소서、TK-NOG소서화근년래적AFC8소서등궤충응용교위엄범차유대표성적인원화소서모형급기재간장질병연구중적응용진행료대비분석，천술료타문각자적모형원리화우결점，이기대인원화소서응용우인류간장질병적연구구유교위직관적인식。
Liver diseases post great threats to human public health globally.Lacking of appropriate small animal models largely impeded the translational studies on human liver diseases, especially on viral hepatitis and related cirrhosis, hepatocellular carcinoma, etc.By human hepatocyte transplantation, the liver-humanized mice have significantly contribu-ted to the researches of human liver diseases.This review summarizes the currently widely used and representative human-ized mouse models, including uPA, FAH, TK-NOG, AFC8 mice and their applications in studies of human liver diseases.