CAJ | 학술논문

目的：近交繁殖先天性脐疝大鼠获得能稳定遗传的大鼠脐疝模型，大鼠脐疝结构观察及治疗。方法每代大鼠全同胞交配，记录产子数及脐疝情况，分析大鼠脐疝率；取F2代6月龄脐疝雌雄大鼠各6只，其中雌雄各2只进行解剖观察，雌雄大鼠各4只进行外科手术缝合。结果随近交系数增大，大鼠脐疝率升高，F12、F13代大鼠均为脐疝；F1代至F13代雌性大鼠总体脐疝率显著高于雄性大鼠（c2＝11.1， P ＝0.001）；雌雄大鼠脐疝结构一致，手术后3～4周痊愈无复发。结论经连续13代全同胞交配获得了遗传性状稳定的大鼠脐疝模型。
목적：근교번식선천성제산대서획득능은정유전적대서제산모형，대서제산결구관찰급치료。방법매대대서전동포교배，기록산자수급제산정황，분석대서제산솔；취F2대6월령제산자웅대서각6지，기중자웅각2지진행해부관찰，자웅대서각4지진행외과수술봉합。결과수근교계수증대，대서제산솔승고，F12、F13대대서균위제산；F1대지F13대자성대서총체제산솔현저고우웅성대서（c2＝11.1， P ＝0.001）；자웅대서제산결구일치，수술후3～4주전유무복발。결론경련속13대전동포교배획득료유전성상은정적대서제산모형。
Objective To obtain a stably inherited Sprague-Dawley rat model of congenital umbilical hernia by in-breeding, and to observe the structure of umbilical hernia and treat it surgically.Methods Congenital umbilical hernia rats were fostered by full-sib mating.The birth number and umbilical hernia quantity were recorded, and the umbilical hernia rate of rats was analyzed.Six female and 6 male rats with congenital umbilical hernia of 6-month aged F2 generation were selected randomly, among which 2 female and 2 male rats were examined anatomically, and the rest rats underwent surgical suture. Results The umbilical hernia rate was increased along with the increasing inbreeding coefficient, and the rats of F12 and F13 generations were all with congenital umbilical hernia.The umbilical hernia rate in female rats was significantly higher than that in male rats based on the total number of rats from F1 to F13 generation (c2 =11.1, P=0.001).Female and male rats had the same structure of umbilical hernia, and all rats recovered 3-4 weeks after surgery without recurrence.Conclusion After 13 consecutive generations of full-sib mating, a rat model of congenital umbilical hernia with stable genetic properties is successfully established.