CAJ | 학술논문

钙、铁、锌、镁、铜是我国儿童保健领域检测较多的矿物质，全血检测操作简单、采血量少，且可以用于检验人体水平，因此，被临床检验和科学研究领域接受。建立儿童全血钙、铁、锌、镁、铜参考值是有意义的。该文综述中国10年来的多地区和单个地区的儿童全血中钙、铁、锌、镁、铜参考值的研究，提出：①各研究中制定参考值的实验室都有质量控制相关操作，但标准不统一，建议建立中国儿童群体自己参考区间，并进行更加规范化的管理；②确定参考区间供临床和科研调查使用，因此，确定了实验室参考区间，只是提供了依据，需要进一步论证；③确定参考区间如果要推广到其他区域，就需要更多的人群参与检测，或使用能反应目标人群的更合理的抽样方法；④争取纳入更多小年龄儿童和农村地区的儿童。
개、철、자、미、동시아국인동보건영역검측교다적광물질，전혈검측조작간단、채혈량소，차가이용우검험인체수평，인차，피림상검험화과학연구영역접수。건립인동전혈개、철、자、미、동삼고치시유의의적。해문종술중국10년래적다지구화단개지구적인동전혈중개、철、자、미、동삼고치적연구，제출：①각연구중제정삼고치적실험실도유질량공제상관조작，단표준불통일，건의건립중국인동군체자기삼고구간，병진행경가규범화적관리；②학정삼고구간공림상화과연조사사용，인차，학정료실험실삼고구간，지시제공료의거，수요진일보론증；③학정삼고구간여과요추엄도기타구역，취수요경다적인군삼여검측，혹사용능반응목표인군적경합리적추양방법；④쟁취납입경다소년령인동화농촌지구적인동。
Calcium ( Ca) , iron ( Fe) , zinc ( Zn) , magnesium ( Mg) and copper ( Cu) are the most common trace elements in blood test for child health assessment in China.Whole blood test of these trace elements has been applied in clinical examination and scientific research for its simple operation and little blood sample needed, and it can be used to evaluate level in the body.It is valuable to build reference intervals for Ca, Fe, Zn, Mg and Cu for Chinese children.This article reviewed the studies of reference intervals for these trace elements in children’ s whole blood in the past decade, and the following suggestions were provided.Reference intervals for Chinese children should be set and more standard management should be taken since the standards for quality control in laboratories of the studies are not unified.Reference intervals are used for clinical diagnosis and prevalence survey, thus defining reference intervals of laboratories provides evidence only and more work is needed to confirm.More population and feasible sampling methods are needed to apply the reference intervals.Furthermore, more studies should be conducted in young children and in rural areas.