中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2014年
5期
808-810
,共3页
妊娠期糖尿病%脂联素%25-羟维生素D%抵抗素
妊娠期糖尿病%脂聯素%25-羥維生素D%牴抗素
임신기당뇨병%지련소%25-간유생소D%저항소
gestational diabetes mellitus (GDM)%adiponectin (ADP)%25(OH)D3%resistin
目的:考察妊娠期糖尿病( GDM)孕期动态血清脂联素( ADP)、25-羟维生素D3[25( OH) D3]和抵抗素的变化与临床意义。方法2013年1月至2014年1月在石家庄市第四医院产科门诊接受产前检查孕妇2000名,均于妊娠11~14周留取血样。所有孕妇均于24~28周行口服葡萄糖耐量试验( OGTT)试验,其中86例孕妇诊断为GDM,选取其为研究对象,随机选取同期产检健康孕妇75例为对照。动态观察孕早、中、晚期血清中ADP、25(OH)D3和抵抗素水平。结果 GDM的发病率为4.3%(86/2000),随孕期进展,对照组和GDM组的中晚期ADP和25(OH)D3水平与早期相比均显著降低(ADP:F值分别为43.3、187.9;25(OH)D3:F值分别为8.7、9.3,均P<0.05);与对照组比较,GDM组孕早、中和晚期ADP和25(OH)D3水平均显著降低(ADP:t值分别为5.0、13.4、14.1;25(OH)D3:t值分别为2.5、2.1、2.2,均P<0.05)。随孕期进展,两组的抵抗素水平中晚期与早期相比均显著增加(F值分别为149.3、56.0,均P<0.05),与对照组比较,GDM组孕早、中和晚期抵抗素水平均显著增加(t值分别为15.8、15.4、10.1,均P<0.05)。结论在妊娠早期综合检测ADP、25(OH)D3和抵抗素有利于综合诊断GDM,并给予及时治疗。
目的:攷察妊娠期糖尿病( GDM)孕期動態血清脂聯素( ADP)、25-羥維生素D3[25( OH) D3]和牴抗素的變化與臨床意義。方法2013年1月至2014年1月在石傢莊市第四醫院產科門診接受產前檢查孕婦2000名,均于妊娠11~14週留取血樣。所有孕婦均于24~28週行口服葡萄糖耐量試驗( OGTT)試驗,其中86例孕婦診斷為GDM,選取其為研究對象,隨機選取同期產檢健康孕婦75例為對照。動態觀察孕早、中、晚期血清中ADP、25(OH)D3和牴抗素水平。結果 GDM的髮病率為4.3%(86/2000),隨孕期進展,對照組和GDM組的中晚期ADP和25(OH)D3水平與早期相比均顯著降低(ADP:F值分彆為43.3、187.9;25(OH)D3:F值分彆為8.7、9.3,均P<0.05);與對照組比較,GDM組孕早、中和晚期ADP和25(OH)D3水平均顯著降低(ADP:t值分彆為5.0、13.4、14.1;25(OH)D3:t值分彆為2.5、2.1、2.2,均P<0.05)。隨孕期進展,兩組的牴抗素水平中晚期與早期相比均顯著增加(F值分彆為149.3、56.0,均P<0.05),與對照組比較,GDM組孕早、中和晚期牴抗素水平均顯著增加(t值分彆為15.8、15.4、10.1,均P<0.05)。結論在妊娠早期綜閤檢測ADP、25(OH)D3和牴抗素有利于綜閤診斷GDM,併給予及時治療。
목적:고찰임신기당뇨병( GDM)잉기동태혈청지련소( ADP)、25-간유생소D3[25( OH) D3]화저항소적변화여림상의의。방법2013년1월지2014년1월재석가장시제사의원산과문진접수산전검사잉부2000명,균우임신11~14주류취혈양。소유잉부균우24~28주행구복포도당내량시험( OGTT)시험,기중86례잉부진단위GDM,선취기위연구대상,수궤선취동기산검건강잉부75례위대조。동태관찰잉조、중、만기혈청중ADP、25(OH)D3화저항소수평。결과 GDM적발병솔위4.3%(86/2000),수잉기진전,대조조화GDM조적중만기ADP화25(OH)D3수평여조기상비균현저강저(ADP:F치분별위43.3、187.9;25(OH)D3:F치분별위8.7、9.3,균P<0.05);여대조조비교,GDM조잉조、중화만기ADP화25(OH)D3수평균현저강저(ADP:t치분별위5.0、13.4、14.1;25(OH)D3:t치분별위2.5、2.1、2.2,균P<0.05)。수잉기진전,량조적저항소수평중만기여조기상비균현저증가(F치분별위149.3、56.0,균P<0.05),여대조조비교,GDM조잉조、중화만기저항소수평균현저증가(t치분별위15.8、15.4、10.1,균P<0.05)。결론재임신조기종합검측ADP、25(OH)D3화저항소유리우종합진단GDM,병급여급시치료。
Objective To study the changes and clinical significance of adiponectin (ADP), 25(OH) D3 and resistin in gestational diabetes mellitus ( GDM) .Methods Blood specimens at gestational age of 11 -14 weeks were collected from 2 000 pregnant women receiving antenatal examination in obstetric clinic of the Fourth Hospital of Shijiazhuang from January 2013 to January 2014.All pregnant women received OGTT test at 24 to 28 weeks, and 86 cases diagnosed with GDM were selected as research objects.Another 75 cases of healthy pregnant women examined at the same period were selected as controls.ADP, 25(OH)D3 and resistin levels at three trimesters of pregnancy were observed dynamically.Results The incidence of GDM was 4.3%(86/2 000) .With the progress of pregnancy, ADP and 25( OH) D3 at second and third trimester in both groups decreased significantly ( ADP: F value was 43.3 and 187.9, respectively;25(OH)D3:F value was 8.7 and 9.3, respectively, all P<0.05).Compared with the control group, the levels of ADP and 25(OH)D3 at three trimesters of pregnancy were significantly reduced in GDM group ( ADP:t value was 5.0, 13.4 and 14.1, respectively;25(OH)D3:t value was 2.5, 2.1 and 2.2, respectively, all P<0.05).Resistin in middle and late pregnancy increased compared with that in early pregnancy in both groups (F value was 149.3 and 56.0, respectively, both P<0.05), and the increase in GDM group was more significant (t value was 15.8, 15.4 and 10.1, respectively, all P<0.05).Conclusion Comprehensive test of ADP, 25(OH)D3 and resistin is helpful to diagnosis of GDM and timely treatment.