CAJ | 학술논문

目的：研究妊娠期高血压疾病（ HDCP）患者外周血活化血小板及血小板-白细胞聚集体的变化，并探讨其与妊娠期高血压的关系。方法采用流式细胞术检测47例妊娠期高血压疾病患者、40例正常健康女性和40例正常妊娠者外周血血小板上的血小板P选择素（CD62p）和血小板纤维蛋白原受体（PAC-1）的表达，以及单核细胞、粒细胞的CD61表达百分率，即血小板-单核细胞聚集体（ PMA）、血小板-粒细胞聚集体（ PNA）。结果妊娠期高血压疾病组的CD62p、PAC-1、PMA、PNA均显著高于正常非孕组和正常妊娠组（t值分别为3．422、3．710、4．014、3．743和3．636、3．427、3．270、3．425，均P＜0．01），且随病情加重越明显。结论外周血活化血小板及血小板-白细胞聚集体的变化与妊娠期高血压疾病的病情有一定的正相关。
목적：연구임신기고혈압질병（ HDCP）환자외주혈활화혈소판급혈소판-백세포취집체적변화，병탐토기여임신기고혈압적관계。방법채용류식세포술검측47례임신기고혈압질병환자、40례정상건강녀성화40례정상임신자외주혈혈소판상적혈소판P선택소（CD62p）화혈소판섬유단백원수체（PAC-1）적표체，이급단핵세포、립세포적CD61표체백분솔，즉혈소판-단핵세포취집체（ PMA）、혈소판-립세포취집체（ PNA）。결과임신기고혈압질병조적CD62p、PAC-1、PMA、PNA균현저고우정상비잉조화정상임신조（t치분별위3．422、3．710、4．014、3．743화3．636、3．427、3．270、3．425，균P＜0．01），차수병정가중월명현。결론외주혈활화혈소판급혈소판-백세포취집체적변화여임신기고혈압질병적병정유일정적정상관。
Objective To investigate the changes of platelet activation and plateletleukocyte aggregates(PLA) of patients with hypertensive disorder complicating pregnancy ( HDCP) , and to explore the relationship between them and HDCP.Methods Flow cytometry was used to detect the expressions of peripheral blood platelet CD62p and PAC-1, and the percentages of platelet monocyte aggregates ( PMA) and platelet neutrophil aggregates ( PNA) of 47 patients with HDCP, 40 healthy women and 40 healthy prenant women.Results The expression of CD62p and PAC-1, PMA and PNA of HDCP group were significantly higher than those of healthy group and healthy pregnant group ( t value was 3.422, 3.710, 4.014,3.743, 3.636, 3.427, 3.270 and 3.425, respectively, all P<0.01).They became higher with the increasing of severity of disease.Conclusion The changes of peripheral blood platelet activation and PLA are positively correlated with HDCP to some extent.