中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2014年
5期
764-766,767
,共4页
徐小博%张西愿%王建%马向东
徐小博%張西願%王建%馬嚮東
서소박%장서원%왕건%마향동
卵巢上皮性肿瘤%基质金属蛋白酶-2%血管内皮生长因子%免疫组织化学
卵巢上皮性腫瘤%基質金屬蛋白酶-2%血管內皮生長因子%免疫組織化學
란소상피성종류%기질금속단백매-2%혈관내피생장인자%면역조직화학
epithelial ovarian tumor%matrix metalloproteinase-2 ( MMP-2 )%vascular endothelial growth factor ( VEGF )%immunohistochemistry
目的：观察基质金属蛋白酶-2（ MMP-2）及血管内皮生长因子（ VEGF）蛋白在卵巢上皮性肿瘤中的表达，并探讨其临床意义。方法采用免疫组织化学检测技术，检测60例卵巢上皮性肿瘤组织及20例正常卵巢组织中MMP-2及VEGF蛋白的表达，并分析其表达与临床病理之间的关系。结果 MMP-2和 VEGF 在上皮性卵巢癌症中的阳性表达率分别为65．0％和75．0％，显著高于正常卵巢组织（χ2值分别为9．697、4．252，均P＜0．05）。 MMP-2和VEGF在高分化、中分化及低分化卵巢上皮性肿瘤中的阳性表达率均存在差异，但无统计学意义（χ2值分别为1．959、2．104，均P＞0．05），即随着组织分化级别的降低，MMP-2和VEGF的阳性表达率在升高。上皮性卵巢癌患者中MMP-2和VEGF蛋白表达呈显著正相关（r＝0．464，P＜0．05）。结论MMP-2及VEGF对卵巢上皮性肿瘤的诊断有参考意义，并且在卵巢上皮性肿瘤的浸润转移中可能发挥重要作用。
目的：觀察基質金屬蛋白酶-2（ MMP-2）及血管內皮生長因子（ VEGF）蛋白在卵巢上皮性腫瘤中的錶達，併探討其臨床意義。方法採用免疫組織化學檢測技術，檢測60例卵巢上皮性腫瘤組織及20例正常卵巢組織中MMP-2及VEGF蛋白的錶達，併分析其錶達與臨床病理之間的關繫。結果 MMP-2和 VEGF 在上皮性卵巢癌癥中的暘性錶達率分彆為65．0％和75．0％，顯著高于正常卵巢組織（χ2值分彆為9．697、4．252，均P＜0．05）。 MMP-2和VEGF在高分化、中分化及低分化卵巢上皮性腫瘤中的暘性錶達率均存在差異，但無統計學意義（χ2值分彆為1．959、2．104，均P＞0．05），即隨著組織分化級彆的降低，MMP-2和VEGF的暘性錶達率在升高。上皮性卵巢癌患者中MMP-2和VEGF蛋白錶達呈顯著正相關（r＝0．464，P＜0．05）。結論MMP-2及VEGF對卵巢上皮性腫瘤的診斷有參攷意義，併且在卵巢上皮性腫瘤的浸潤轉移中可能髮揮重要作用。
목적：관찰기질금속단백매-2（ MMP-2）급혈관내피생장인자（ VEGF）단백재란소상피성종류중적표체，병탐토기림상의의。방법채용면역조직화학검측기술，검측60례란소상피성종류조직급20례정상란소조직중MMP-2급VEGF단백적표체，병분석기표체여림상병리지간적관계。결과 MMP-2화 VEGF 재상피성란소암증중적양성표체솔분별위65．0％화75．0％，현저고우정상란소조직（χ2치분별위9．697、4．252，균P＜0．05）。 MMP-2화VEGF재고분화、중분화급저분화란소상피성종류중적양성표체솔균존재차이，단무통계학의의（χ2치분별위1．959、2．104，균P＞0．05），즉수착조직분화급별적강저，MMP-2화VEGF적양성표체솔재승고。상피성란소암환자중MMP-2화VEGF단백표체정현저정상관（r＝0．464，P＜0．05）。결론MMP-2급VEGF대란소상피성종류적진단유삼고의의，병차재란소상피성종류적침윤전이중가능발휘중요작용。
Objective To observe the expressions of matrix metalloproteinase 2 (MMP-2) and vascular endothelial growth factor (VEGF) in epithelial ovarian tumors, and explore their clinical significance.Methods The expressions of MMP-2 and VEGF protein in tissues of 60 cases with epithelial ovarian tumors and in tissues of 20 cases with normal ovarian were detected by immunohistochemical technology, and their relationship with clinical pathology were analyzed.Results The positive expressions of MMP-2 and VEGF protein in epithelial ovarian carcinomas were 65.0%and 75.0%, respectively, which were significantly higher than in normal ovarian tissues (χ2 value was 9.697 and 4.252, respectively, both P<0.05).There were differences in epithelial ovarian tumors with high differentiation, middle differentiation and low differentiation between MMP-2 and VEGF (χ2 value was 1.959 and 2.104, respectively, both P >0.05 ) without statistical significance.With the reduction of tissue differentiation, the positive expression rate of MMP-2 and VEGF increased.There was significant positive correlation between MMP-2 and VEGF in patients with epithelial ovarian carcinoma (r=0.464, P<0.05).Conclusion MMP-2 and VEGF have reference significance for the diagnosis of epithelial ovarian tumor, and they play an important role in invasion and metastasis of epithelial ovarian tumor.
