中华老年心脑血管病杂志
中華老年心腦血管病雜誌
중화노년심뇌혈관병잡지
CHINESE JOURNAL OF GERIATRIC CARDIOVASCULAR AND CEREBROVASCULAR DISEASES
2014年
10期
1061-1064
,共4页
付文亭%李清%邵长娟%徐思振
付文亭%李清%邵長娟%徐思振
부문정%리청%소장연%서사진
颅内动脉硬化%脑梗死%动脉粥样硬化%栓子%血流动力学%危险因素
顱內動脈硬化%腦梗死%動脈粥樣硬化%栓子%血流動力學%危險因素
로내동맥경화%뇌경사%동맥죽양경화%전자%혈류동역학%위험인소
intracranial arteriosclerosis%brain infarction%atherosclerosis%embolus%hemodynamic%risk factors
目的:探讨脑动脉粥样硬化性狭窄与急性脑梗死进展发生的联系。方法回顾性分析2011年1月~2014年1月在我院住院治疗的急性单发皮质下小梗死患者272例,根据入院3d是否发生进展性神经功能障碍(PND)分为PND组64例,非PND组208例。所有患者神经功能评估采用美国国立卫生研究院卒中量表(NIHSS)评分,以入院3d内复评NIHSS评分,入院时增加≥2分或运动功能缺损波动≥1分为PND。根据脑血管检查结果将入组患者的脑血管动脉粥样硬化病变分为颅内、颅外及前、后循环系统,比较2组患者间各系统动脉粥样硬化性狭窄发生的差异。结果与非PND组比较,PND组女性比例明显升高(45.3%vs31.7%,P=0.046)、NIHSS评分明显升高[7(4,9)分vs6(3,8)分,P=0.033]、病灶≥15mm比例更高(42.2%vs28.8%,P=0.045)、颅内动脉粥样硬化性狭窄(45.3%vs29.8%,P=0.022)和颅外动脉粥样硬化性狭窄比例更高(53.1%vs38.0%,P=0.032),差异有统计学意义。logistic回归分析显示,颅内动脉粥样硬化性狭窄是PND发生的独立危险因素(OR=1.961,95%CI:1.070~3.592,P=0.029)。结论颅内动脉粥样硬化性狭窄是急性缺血性脑卒中早期发生PND的独立危险因素。
目的:探討腦動脈粥樣硬化性狹窄與急性腦梗死進展髮生的聯繫。方法迴顧性分析2011年1月~2014年1月在我院住院治療的急性單髮皮質下小梗死患者272例,根據入院3d是否髮生進展性神經功能障礙(PND)分為PND組64例,非PND組208例。所有患者神經功能評估採用美國國立衛生研究院卒中量錶(NIHSS)評分,以入院3d內複評NIHSS評分,入院時增加≥2分或運動功能缺損波動≥1分為PND。根據腦血管檢查結果將入組患者的腦血管動脈粥樣硬化病變分為顱內、顱外及前、後循環繫統,比較2組患者間各繫統動脈粥樣硬化性狹窄髮生的差異。結果與非PND組比較,PND組女性比例明顯升高(45.3%vs31.7%,P=0.046)、NIHSS評分明顯升高[7(4,9)分vs6(3,8)分,P=0.033]、病竈≥15mm比例更高(42.2%vs28.8%,P=0.045)、顱內動脈粥樣硬化性狹窄(45.3%vs29.8%,P=0.022)和顱外動脈粥樣硬化性狹窄比例更高(53.1%vs38.0%,P=0.032),差異有統計學意義。logistic迴歸分析顯示,顱內動脈粥樣硬化性狹窄是PND髮生的獨立危險因素(OR=1.961,95%CI:1.070~3.592,P=0.029)。結論顱內動脈粥樣硬化性狹窄是急性缺血性腦卒中早期髮生PND的獨立危險因素。
목적:탐토뇌동맥죽양경화성협착여급성뇌경사진전발생적련계。방법회고성분석2011년1월~2014년1월재아원주원치료적급성단발피질하소경사환자272례,근거입원3d시부발생진전성신경공능장애(PND)분위PND조64례,비PND조208례。소유환자신경공능평고채용미국국립위생연구원졸중량표(NIHSS)평분,이입원3d내복평NIHSS평분,입원시증가≥2분혹운동공능결손파동≥1분위PND。근거뇌혈관검사결과장입조환자적뇌혈관동맥죽양경화병변분위로내、로외급전、후순배계통,비교2조환자간각계통동맥죽양경화성협착발생적차이。결과여비PND조비교,PND조녀성비례명현승고(45.3%vs31.7%,P=0.046)、NIHSS평분명현승고[7(4,9)분vs6(3,8)분,P=0.033]、병조≥15mm비례경고(42.2%vs28.8%,P=0.045)、로내동맥죽양경화성협착(45.3%vs29.8%,P=0.022)화로외동맥죽양경화성협착비례경고(53.1%vs38.0%,P=0.032),차이유통계학의의。logistic회귀분석현시,로내동맥죽양경화성협착시PND발생적독립위험인소(OR=1.961,95%CI:1.070~3.592,P=0.029)。결론로내동맥죽양경화성협착시급성결혈성뇌졸중조기발생PND적독립위험인소。
Objective To study the relation between intracranial atherosclerotic stenosis and acute ischemic stroke (AIS) progression .Methods Two hundred and seventy-two AIS patients admit-ted to our hospital from January 2011 and January 2014 were divided into progressive neurological dysfunction (PND) group (n=64) and non-PND group (n=208) .Cerebral atherosclerotic lesions were divided into intracranial circulation system lesion ,extracranial circulation system lesion ,an-terior circulation system lesion ,and posterior circulation system lesion according to their angio-graphic findings .Incidence of atherosclerotic stenosis in different circulation systems was com-pared .Results The proportion of female patients ,lesion size≥15 mm ,intracranial atherosclerotic stenosis ,and extracranial atherosclerotic stenosis was significantly higher in PND group than in non-PND group (45 .3% vs 31 .7% ,P=0 .046 ;42 .2% vs 28 .8% ,P=0 .045;45 .3% vs 29 .8% , P=0 .022 ;53 .1% vs 38 .0% ,P=0 .032) .The NIHSS scale was significantly higher in PND group than in non-PND group[7(4 ,9) vs 6(3 ,8) ,P=0 .033] .Logistic regression analysis showed that intracranial atherosclerotic stenosis was an independent risk factor for PND (OR=1 .961 ,95% CI:1 .070-3.592 ,P=0 .029) .Conclusion Intracranial atherosclerotic stenosis is an independent risk factor for early PND in AIS patients .