中华老年心脑血管病杂志
中華老年心腦血管病雜誌
중화노년심뇌혈관병잡지
CHINESE JOURNAL OF GERIATRIC CARDIOVASCULAR AND CEREBROVASCULAR DISEASES
2014年
10期
1044-1047
,共4页
梅刚%公丕裕%罗群%陆蓉%徐俊%顾小花%韦存胜%蔡荇%瞿秋霜%李海林
梅剛%公丕裕%囉群%陸蓉%徐俊%顧小花%韋存勝%蔡荇%瞿鞦霜%李海林
매강%공비유%라군%륙용%서준%고소화%위존성%채행%구추상%리해림
认知障碍%阿尔茨海默病%痴呆%ROC曲线
認知障礙%阿爾茨海默病%癡呆%ROC麯線
인지장애%아이자해묵병%치태%ROC곡선
cognition disorders%Alzheimer disease%dementia%ROC curve
目的:对认知障碍初步评价表(COG-12)在阿尔茨海默病(AD)患者中的信度与效度进行评价。方法选择2013年1~12月就诊于南京医科大学附属脑科医院老年精神科的 AD患者148例为AD组,另选择社区志愿者365例为对照组,2组均接受临床痴呆量表、AD8、简易智能状态检查量表、画钟测验评估和COG-12测评。其中100例AD患者知情者在首次评定1个月内重测COG-12。结果 COG-12的克朗巴赫α系数=0.883,重测信度=0.883(P<0.01)。COG-12各条目评分与总分的相关系数为0.41~0.79(P<0.05,P<0.01);COG-12总分与简易智能状态检量表、画钟测验呈负相关(r=-0.67,r=-0.27,P<0.01),与临床痴呆量表、AD8总分呈正相关(r=0.80,r=0.81,P<0.01)。COG-12鉴别认知正常与轻度AD患者的ROC曲线下面积=0.902,≥6分为认知损害的界限分值敏感性为90.0%,特异性为82.5%;鉴别轻度与中度AD患者的ROC曲线下面积=0.898,敏感性为90.5%,特异性为76.7%。结论 COG-12具有良好的信度和效度,是快速识别痴呆及评估严重程度敏感而准确的筛查评估工具。
目的:對認知障礙初步評價錶(COG-12)在阿爾茨海默病(AD)患者中的信度與效度進行評價。方法選擇2013年1~12月就診于南京醫科大學附屬腦科醫院老年精神科的 AD患者148例為AD組,另選擇社區誌願者365例為對照組,2組均接受臨床癡呆量錶、AD8、簡易智能狀態檢查量錶、畫鐘測驗評估和COG-12測評。其中100例AD患者知情者在首次評定1箇月內重測COG-12。結果 COG-12的剋朗巴赫α繫數=0.883,重測信度=0.883(P<0.01)。COG-12各條目評分與總分的相關繫數為0.41~0.79(P<0.05,P<0.01);COG-12總分與簡易智能狀態檢量錶、畫鐘測驗呈負相關(r=-0.67,r=-0.27,P<0.01),與臨床癡呆量錶、AD8總分呈正相關(r=0.80,r=0.81,P<0.01)。COG-12鑒彆認知正常與輕度AD患者的ROC麯線下麵積=0.902,≥6分為認知損害的界限分值敏感性為90.0%,特異性為82.5%;鑒彆輕度與中度AD患者的ROC麯線下麵積=0.898,敏感性為90.5%,特異性為76.7%。結論 COG-12具有良好的信度和效度,是快速識彆癡呆及評估嚴重程度敏感而準確的篩查評估工具。
목적:대인지장애초보평개표(COG-12)재아이자해묵병(AD)환자중적신도여효도진행평개。방법선택2013년1~12월취진우남경의과대학부속뇌과의원노년정신과적 AD환자148례위AD조,령선택사구지원자365례위대조조,2조균접수림상치태량표、AD8、간역지능상태검사량표、화종측험평고화COG-12측평。기중100례AD환자지정자재수차평정1개월내중측COG-12。결과 COG-12적극랑파혁α계수=0.883,중측신도=0.883(P<0.01)。COG-12각조목평분여총분적상관계수위0.41~0.79(P<0.05,P<0.01);COG-12총분여간역지능상태검량표、화종측험정부상관(r=-0.67,r=-0.27,P<0.01),여림상치태량표、AD8총분정정상관(r=0.80,r=0.81,P<0.01)。COG-12감별인지정상여경도AD환자적ROC곡선하면적=0.902,≥6분위인지손해적계한분치민감성위90.0%,특이성위82.5%;감별경도여중도AD환자적ROC곡선하면적=0.898,민감성위90.5%,특이성위76.7%。결론 COG-12구유량호적신도화효도,시쾌속식별치태급평고엄중정도민감이준학적사사평고공구。
Objective To assess the validity and reliability of COG-12 in Alzheimer's disease (AD) patients .Methods One hundred and forty-eight AD patients served as an AD group and 365 vol-unteers served as a control group in this study .Patients in two groups were assessed according to the AD8 ,CDR ,MMSE ,CDT and COG-12 ,respectively .Of the 148 AD patients ,100 were reas-sessed according to the COG-12 .Results T he Cronbach alpha coefficient and retested intraclass correlation coefficient for COG-12 were 0 .883 and 0 .883 ,respectively (P<0 .01) .The correlation coefficient for each COG-12 item score and total COG-12 score was 0 .41 -0 .79 (P< 0.05 ,P<0.01) .The total COG-12 score was negatively correlated with the MMSE and CDT ,and positively correlated with the total CDR and AD8 score (r= -0 .67 ,r= -0 .27 ,P<0 .01 ;r=0 .80 ,r=0.81 , P<0 .01) .The area under the ROC curve was 0 .902 when those with normal recognition and mild AD patients were identified according to the COG-12 with a sensitivity of 90 .0% and a specificity of 82 .5% when its cutoff was ≥6 .The area under the ROC curve was 0 .898 when the mild and moderate AD patients were identified according to the COG-12 with a sensitivity of 90.5% and a specificity of 76 .7% .Conclusion COG-12 ,with a good validity and reliability ,is a sensitive and accurate tool for the rapid screen of dementia and assessment of its severity .