CAJ | 학술논문

目的：探讨老年心力衰竭（CHF）患者心功能与血浆B型钠尿肽（BNP）和血尿酸的相关性。方法选择132例老年CHF患者作为CHF组，并按心功能分级（NYHA）Ⅰ级26例、Ⅱ级38例、Ⅲ级40例、Ⅳ级28例。同期选择健康体检者50例作为对照组。分别测定血浆BNP及血尿酸水平，比较不同心功能级别入选患者的血浆BNP水平和血尿酸水平。结果 CHF组患者血浆BNP和血尿酸水平明显高于对照组，差异有统计学意义[（784．19±206．00）ng/L vs （41．25±15．34）ng/L ，（405．24±90．16）μmol/L vs （286．43±78．68）μmol/L ，P＜0．01]；不同心功能分级患者血浆BNP和血尿酸水平两两比较，差异有统计学意义（P＜0．05，P＜0．01）；CHF时，BNP与心功能分级、血尿酸、左心室舒张末内径（LVEDD）呈正相关（r＝0．76、0．33、0．22，P＜0．05）；与 LVEF呈负相关（r＝-0．34，P＜0．05）；尿酸与心功能分级、LVEDD 呈正相关（r＝0．41、0．23，P＜0．05）；与 LVEF呈负相关（r＝-0．24，P＜0．05）。结论血浆BNP和血尿酸水平与心功能分级可能具有相关性。
목적：탐토노년심력쇠갈（CHF）환자심공능여혈장B형납뇨태（BNP）화혈뇨산적상관성。방법선택132례노년CHF환자작위CHF조，병안심공능분급（NYHA）Ⅰ급26례、Ⅱ급38례、Ⅲ급40례、Ⅳ급28례。동기선택건강체검자50례작위대조조。분별측정혈장BNP급혈뇨산수평，비교불동심공능급별입선환자적혈장BNP수평화혈뇨산수평。결과 CHF조환자혈장BNP화혈뇨산수평명현고우대조조，차이유통계학의의[（784．19±206．00）ng/L vs （41．25±15．34）ng/L ，（405．24±90．16）μmol/L vs （286．43±78．68）μmol/L ，P＜0．01]；불동심공능분급환자혈장BNP화혈뇨산수평량량비교，차이유통계학의의（P＜0．05，P＜0．01）；CHF시，BNP여심공능분급、혈뇨산、좌심실서장말내경（LVEDD）정정상관（r＝0．76、0．33、0．22，P＜0．05）；여 LVEF정부상관（r＝-0．34，P＜0．05）；뇨산여심공능분급、LVEDD 정정상관（r＝0．41、0．23，P＜0．05）；여 LVEF정부상관（r＝-0．24，P＜0．05）。결론혈장BNP화혈뇨산수평여심공능분급가능구유상관성。
Objective To study the correlation of heart function with plasma BNP and serum uric acid (UA) levels in elderly heart failure patients .Methods One hundred and thirty-two elderly patients with chronic heart failure (CHF)served as a CHF group in this study .They were divided into class Ⅰ group (n=26) ,class Ⅱ group (n=38) ,class Ⅲ group (n=40) ,and class Ⅳ group (n=28) according to the NYHA Classification .Fifty healthy subjects undergoing physical exami-nation served as a control group .Their plasma BNP and erum UA levels were measured and com-pared .Results The plasma BNP and erum UA levels were significantly higher in CHF group than in control group (784 .19 ± 206 .00 ng/L vs 41 .25 ± 15 .34 ng/L ,405 .24 ± 90 .16 μmol/L vs 286 .43 ± 78 .68 μmol/L ,P<0 .01) and were significantly different in class Ⅰ - Ⅳ groups (P<0.05 ,P<0 .01) .The plasma BNP level was positively correlated with the NYHA Classification , serum UA level and LVEDD ,and negatively correlated with the LVEF in CHF patients (r=0 .76 , 0 .33 ,0 .22 ,P<0 .05 ;r= -0 .34 ,P<0 .0 5) .The serum UA level was positively correlated with the NYHA Classification and LVEDD ,and negatively correlated with the LVEF in CHF patients (r=0 .41 ,0 .23 ,P<0 .05 ;r= -0 .24 ,P<0 .05) .Conclusion Plasma BNP and serum UA levels are correlated with the cardiac function classification in CHF patients .