中华老年心脑血管病杂志
中華老年心腦血管病雜誌
중화노년심뇌혈관병잡지
CHINESE JOURNAL OF GERIATRIC CARDIOVASCULAR AND CEREBROVASCULAR DISEASES
2014年
10期
1038-1040
,共3页
侯金泓%王剑利%李俊娟%黄金杰%周靖%刘艳%吴寿岭
侯金泓%王劍利%李俊娟%黃金傑%週靖%劉豔%吳壽嶺
후금홍%왕검리%리준연%황금걸%주정%류염%오수령
肾小球滤过率%肾功能不全%血压%危险因素
腎小毬濾過率%腎功能不全%血壓%危險因素
신소구려과솔%신공능불전%혈압%위험인소
glomerular filtration rate%renal insufficiency%blood pressure%risk factors
目的:研究脉压水平对老年人群远期肾功能的影响。方法用前瞻性队列研究法,选择开滦集团年龄≥60岁健康体检者9695例,以脉压水平分为:脉压<40mmHg(1mm Hg=0.133kPa,1组)972例、40~49mmHg(2组)2393例、50~59mmHg(3组)2553例、脉压≥60mmHg(4组)3777例,以估算肾小球滤过率(eGFR)<60ml/(min·1.73m2)为肾功能受损。随访24~63(50.84±4.83)个月,用Kaplan-Meier法及多因素Cox回归模型分析脉压对远期肾功能的影响。结果1组、2组、3组和4组肾功能受损分别为11例、71例、81例和189例(1.1%vs3.0%vs3.2%vs5.0%,P<0.01)。校正传统危险因素后,与1组比较,其他3组发生肾功能受损的相对风险分别为2.67(95%CI:1.33~5.38,P<0.01)、2.98(95%CI:1.49~5.96,P<0.01)和4.90(95%CI:2.50~9.63,P<0.01)。结论脉压是老年人远期肾功能受损事件的独立危险因素,脉压升高,远期新发肾功能受损增加。
目的:研究脈壓水平對老年人群遠期腎功能的影響。方法用前瞻性隊列研究法,選擇開灤集糰年齡≥60歲健康體檢者9695例,以脈壓水平分為:脈壓<40mmHg(1mm Hg=0.133kPa,1組)972例、40~49mmHg(2組)2393例、50~59mmHg(3組)2553例、脈壓≥60mmHg(4組)3777例,以估算腎小毬濾過率(eGFR)<60ml/(min·1.73m2)為腎功能受損。隨訪24~63(50.84±4.83)箇月,用Kaplan-Meier法及多因素Cox迴歸模型分析脈壓對遠期腎功能的影響。結果1組、2組、3組和4組腎功能受損分彆為11例、71例、81例和189例(1.1%vs3.0%vs3.2%vs5.0%,P<0.01)。校正傳統危險因素後,與1組比較,其他3組髮生腎功能受損的相對風險分彆為2.67(95%CI:1.33~5.38,P<0.01)、2.98(95%CI:1.49~5.96,P<0.01)和4.90(95%CI:2.50~9.63,P<0.01)。結論脈壓是老年人遠期腎功能受損事件的獨立危險因素,脈壓升高,遠期新髮腎功能受損增加。
목적:연구맥압수평대노년인군원기신공능적영향。방법용전첨성대렬연구법,선택개란집단년령≥60세건강체검자9695례,이맥압수평분위:맥압<40mmHg(1mm Hg=0.133kPa,1조)972례、40~49mmHg(2조)2393례、50~59mmHg(3조)2553례、맥압≥60mmHg(4조)3777례,이고산신소구려과솔(eGFR)<60ml/(min·1.73m2)위신공능수손。수방24~63(50.84±4.83)개월,용Kaplan-Meier법급다인소Cox회귀모형분석맥압대원기신공능적영향。결과1조、2조、3조화4조신공능수손분별위11례、71례、81례화189례(1.1%vs3.0%vs3.2%vs5.0%,P<0.01)。교정전통위험인소후,여1조비교,기타3조발생신공능수손적상대풍험분별위2.67(95%CI:1.33~5.38,P<0.01)、2.98(95%CI:1.49~5.96,P<0.01)화4.90(95%CI:2.50~9.63,P<0.01)。결론맥압시노년인원기신공능수손사건적독립위험인소,맥압승고,원기신발신공능수손증가。
Objective To study the effect of PP on long-term kidney function in the elderly .Meth-ods A total of 9695 healthy people with their age ≥60 years who underwent physical examina-tion in our hospital were divided into PP< 40 mm Hg group (group 1 ,n= 972) ,PP= 40 -49 mm Hg group (group 2 ,n=2393) ,PP=50 -59 mm Hg group (group 3 ,n=2553) ,and PP≥60 mm Hg group (group 4 ,n=3777) .Impaired kidney function was defined when the eGFR was <60 ml/(min · 1 .73 m2 ) .The elderly were followed up for 24 -63 (50 .84 ± 4 .83) months .The effect of PP on long-term kidney function was analyzed using the Kaplan-Meier method and multi-variate Cox proportional hazard regression model .Results Impaired kidney function was detected in 352 of the followed up elderly ,namely in 11 of group 1 ,in 71 of group 2 ,in 81 of group 3 ,and in 189 of group 4 (1.1% vs 3 .0% vs 3.2% vs 5 .0% ,P<0 .01) .After adjustment for traditional risk factors ,the relative risk coefficient was 2 .67 (95% CI:1 .33-5 .38) ,2 .98 (95% CI:1 .49-5 .96) , and 4 .90 (95% CI:2 .50-9 .63) ,respectively ,in groups 2-4 ,which was higher than that in group 1 (P<0 .01) .Conclusion PP is an independent risk factor for impaired kidney function in the eld-erly .New kidney funtion impairment increases with the increasing PP .