CAJ | 학술논문

目的观察开喉剑喷雾剂（儿童型）联合热毒宁注射液治疗疱疹性咽峡炎的疗效及不良反应。方法将100例疱疹性咽峡炎患儿分为治疗组55例和对照组45例。治疗组给予开喉剑喷雾剂（儿童型）喷口腔疱疹局部治疗联合热毒宁注射液静脉滴注，对照组给予西瓜霜喷剂喷口腔疱疹局部治疗联合利巴韦林注射液静脉滴注，疗程5～7 d，并根据病情给予相应对症支持治疗。比较两组临床疗效及各项临床疗效观察指标和不良反应。结果治疗组显效30例，有效20例，无效5例；对照组显效20例，有效15例，无效10例，两组疗效差异无统计学意义（ P＞0.05）。但退热时间、口痛消失时间及疱疹溃疡消退时间，治疗组明显优于对照组，差异有统计学意义（ P均＜0.01）。对照组有18例出现白细胞总数减少或粒细胞比值下降，治疗组未见不良反应。结论开喉剑喷雾剂（儿童型）联合毒宁注射液治疗疱疹性咽峡炎疗效确切，安全性高，值得临床推广。
목적관찰개후검분무제（인동형）연합열독저주사액치료포진성인협염적료효급불량반응。방법장100례포진성인협염환인분위치료조55례화대조조45례。치료조급여개후검분무제（인동형）분구강포진국부치료연합열독저주사액정맥적주，대조조급여서과상분제분구강포진국부치료연합리파위림주사액정맥적주，료정5～7 d，병근거병정급여상응대증지지치료。비교량조림상료효급각항림상료효관찰지표화불량반응。결과치료조현효30례，유효20례，무효5례；대조조현효20례，유효15례，무효10례，량조료효차이무통계학의의（ P＞0.05）。단퇴열시간、구통소실시간급포진궤양소퇴시간，치료조명현우우대조조，차이유통계학의의（ P균＜0.01）。대조조유18례출현백세포총수감소혹립세포비치하강，치료조미견불량반응。결론개후검분무제（인동형）연합독저주사액치료포진성인협염료효학절，안전성고，치득림상추엄。
Objective To investigate clinical effects and adverse reactions of Kaihoujian sprays( child type) combined with Reduning injection in treating children with herpangina.Methods One hundred children with herpan-gina were divided into two groups.Fifty-five patients served as treatment group were given Reduning injection intrave-nously.Forty-five children regarded as the control group were given Watermelon frost sprays, which is widely used in local treatment and Ribavirin injection intravenously,for a full period of 5~7 days, and were given local kaihoujian sprays combined with conbi a supportive treatment according to the conditions of the disease.The observation indexes of the clinical efficacies and the clinical curative effect, and adverse reactions were compared between the two groups. Results The treatment group was 30 cases of significant effect, effective 20 cases, invalid in 5 cases;20 cases of control group were significant effect, 15 cases were effective, 10 cases ineffective, there was no statistically signifi-cant difference between the two groups in curative effect( P>0.05) .But defervescence time, mouth pain disappea-ring and Herpetic ulcer healing in treatment group was considerably better than the control group, the difference was statistically significant(P <0.01).The total number of white blood cells or the ratio of neutrophils decreased in 18 patients in the control group.There was no adverse reactions in treatment group.Conclusion Therapeutic effect of Kaihoujian sprays( child type) combined with Reduning injection in treating children with herpangina is significant, which is safety.