CAJ | 학술논문

目的：探讨低频重复经颅刺激对于改善老年精神分裂症患者顽固性幻听和认知功能的临床应用价值。方法按就诊顺序编号将100例老年精神分裂症患者分为对照组和观察组，每组50例。对照组给予利培酮治疗；观察组联用利培酮与低频重复经颅刺激治疗。于治疗前后采用听幻觉量表（ AHRS）及副反应量表（ TESS）对患者进行测评，同时评估患者的词语流.性及连线实验表现。结果经8周治疗后，观察组的幻听评分明显低于对照组，组间比较差异具有统计学意义（P＜0.05）。观察组词语流.性明显优于治疗前（P＜0.05）。对照组词语流.性治疗前后比较差异无统计学意义（ P＞0.05）。连线实验结果显示，两组患者治疗前后比较差异均无统计学意义（ P＞0.05）。结论低频重复经颅刺激可有效改善老年精神分裂症患者顽固性幻听，对改善其认知功能具有一定效果，值得临床借鉴和推广。
목적：탐토저빈중복경로자격대우개선노년정신분렬증환자완고성환은화인지공능적림상응용개치。방법안취진순서편호장100례노년정신분렬증환자분위대조조화관찰조，매조50례。대조조급여리배동치료；관찰조련용리배동여저빈중복경로자격치료。우치료전후채용은환각량표（ AHRS）급부반응량표（ TESS）대환자진행측평，동시평고환자적사어류.성급련선실험표현。결과경8주치료후，관찰조적환은평분명현저우대조조，조간비교차이구유통계학의의（P＜0.05）。관찰조사어류.성명현우우치료전（P＜0.05）。대조조사어류.성치료전후비교차이무통계학의의（ P＞0.05）。련선실험결과현시，량조환자치료전후비교차이균무통계학의의（ P＞0.05）。결론저빈중복경로자격가유효개선노년정신분렬증환자완고성환은，대개선기인지공능구유일정효과，치득림상차감화추엄。
Objective To explroe the clinical value of low frequency repetitive transcranial magnetic stimula-tion in improving obstinate auditory hallucinations and cognitive function in patients with schizophrenia.Methods According to visit order number 100 patients with schizophrenia were divided into control group and observation group,with 50 cases in each group.The control group was treated with risperidone.The observation group was treated by risperidone combined with low frequency repetitive transcranial magnetic stimulation.Before and after treatment, the patients were evaluated, by auditory hallucinationsrating scale( AHRS) and Treatment Emergent Symptom Scale ( TESS) and assessment of verbal fluency and trail making were performal in patients.Results After 8 weeks of treatment,the AHRS scores in the observation group were lower than that in the control group, with statistical signifi-cance between two groups(P<0.05); The observation group′s verbal fluency obviously improved than before treat-ment(P<0.05), the control group′s verbal fluency did not show no significant improvement(P>0.05).There was no significant difference in trail making between the two groups before and after treatment(P>0.05).Conclusion Low frequency repetitive transcranial magnetic stimulation can effectively improve obstinate auditory hallucinations in elderly patients with schizophrenia, and has certain effect in improving their cognitive function,and is worthy of clini-cal reference and promotion.