中国人兽共患病学报
中國人獸共患病學報
중국인수공환병학보
CHINESE JOURNAL OF ZOONOSES
2014年
10期
1071-1074
,共4页
荔童(综述)%张示杰(审校)
荔童(綜述)%張示傑(審校)
려동(종술)%장시걸(심교)
泡状棘球蚴%血管%浸袭性生长%VEGF%CD34
泡狀棘毬蚴%血管%浸襲性生長%VEGF%CD34
포상극구유%혈관%침습성생장%VEGF%CD34
alveolar echinococcosis%vascular%invasive growth%VEGF%CD34
泡球蚴病是对人体危害极大地人兽共患寄生虫病，原发于肝脏，呈恶性浸润性生长，可继发肺、脑转移，手术及药物治疗效果差，其浸润性生长和转移的机制尚不明确，血管新生在正常组织中是被高度管制的行为，异常情况下的血管新生是恶性肿瘤的关键标志之一。VEGF是血管新生中关键的介质。研究显示VEGF和CD34在肿瘤新生血管形成及侵袭性生长过程中起着重要作用。本文初步探讨血管生成在泡球蚴侵袭性中的作用，为临床上泡球蚴病晚期患者的保守治疗、以及手术、药物的辅助治疗提供一个新途径。
泡毬蚴病是對人體危害極大地人獸共患寄生蟲病，原髮于肝髒，呈噁性浸潤性生長，可繼髮肺、腦轉移，手術及藥物治療效果差，其浸潤性生長和轉移的機製尚不明確，血管新生在正常組織中是被高度管製的行為，異常情況下的血管新生是噁性腫瘤的關鍵標誌之一。VEGF是血管新生中關鍵的介質。研究顯示VEGF和CD34在腫瘤新生血管形成及侵襲性生長過程中起著重要作用。本文初步探討血管生成在泡毬蚴侵襲性中的作用，為臨床上泡毬蚴病晚期患者的保守治療、以及手術、藥物的輔助治療提供一箇新途徑。
포구유병시대인체위해겁대지인수공환기생충병，원발우간장，정악성침윤성생장，가계발폐、뇌전이，수술급약물치료효과차，기침윤성생장화전이적궤제상불명학，혈관신생재정상조직중시피고도관제적행위，이상정황하적혈관신생시악성종류적관건표지지일。VEGF시혈관신생중관건적개질。연구현시VEGF화CD34재종류신생혈관형성급침습성생장과정중기착중요작용。본문초보탐토혈관생성재포구유침습성중적작용，위림상상포구유병만기환자적보수치료、이급수술、약물적보조치료제공일개신도경。
Alveolar echinococcosis (AE) is a potentially fatal zoonosis caused by Echinococcus multilocularis (E .m) , primary located in the liver and showed malignant invasion .AE can develop to the lungs and brain metastases .Operation treat-ment and medication therapeutic efficacy show poor effect .The mechanism of AE invasive growth and metastasis is unclear . Angiogenesis is a highly regulated behavior in normal tissues .Abnormal angiogenesis is one of the key signs of malignant tumor ,and VEGF is one of the key mediators of angiogenesis .Numerous studies have shown that VEGF and CD34 plays an important role in the formation of tumor angiogenesis and invasive growth process .This article discussed the role of angiogene-sis in AE aggressive ,aimed to provide a new way for the clinic conservative treatment for patients with advanced stage ,preven-ting recurrence after operation ,and adjunctive therapy of operation and drug .
