检验医学
檢驗醫學
검험의학
LABORATORY MEDICINE
2014年
10期
1031-1033
,共3页
淀粉样蛋白 A%C 反应蛋白%感染性疾病组%联合检测
澱粉樣蛋白 A%C 反應蛋白%感染性疾病組%聯閤檢測
정분양단백 A%C 반응단백%감염성질병조%연합검측
Amyloid A%C-reactive protein%Inflammatory disease group%Combined determination
目的：评估血清淀粉样蛋白A（SAA）与C 反应的蛋白（CRP）联合检测的临床应用价值。方法采用胶体金法和免疫散射比浊法对82例感染性疾病组（包括15例肺炎、23例急性支气管炎、17例急性阑尾炎、16例急性胆囊炎、11例胰腺炎）患者及92名正常对照组的血清 SAA 和 CRP 水平进行检测，并比较两者间的浓度中位数及各疾病组的阳性检出率。结果感染性疾病组患者血清 SAA 与 CRP 浓度中位数水平分别为149．50 mg/L、34．20 mg/L，明显高于正常对照组分别为4．60 mg/L、3．82 mg/L，差异有统计学意义（P ＜0．05）；感染性疾病组血清 SAA，与 CRP 阳性检出率分别为87．80％与79．26％。结论感染性疾病时，SAA 与 CRP 水平变化趋势基本一致，且较 CRP 更为敏感。SAA 与 CRP 都可作为一种监测炎症的有价值的标志物[1]，SAA 与CRP 联合检测可以更有效的提高感染性疾病的检出率，为临床医生提供更敏感的诊断依据。
目的：評估血清澱粉樣蛋白A（SAA）與C 反應的蛋白（CRP）聯閤檢測的臨床應用價值。方法採用膠體金法和免疫散射比濁法對82例感染性疾病組（包括15例肺炎、23例急性支氣管炎、17例急性闌尾炎、16例急性膽囊炎、11例胰腺炎）患者及92名正常對照組的血清 SAA 和 CRP 水平進行檢測，併比較兩者間的濃度中位數及各疾病組的暘性檢齣率。結果感染性疾病組患者血清 SAA 與 CRP 濃度中位數水平分彆為149．50 mg/L、34．20 mg/L，明顯高于正常對照組分彆為4．60 mg/L、3．82 mg/L，差異有統計學意義（P ＜0．05）；感染性疾病組血清 SAA，與 CRP 暘性檢齣率分彆為87．80％與79．26％。結論感染性疾病時，SAA 與 CRP 水平變化趨勢基本一緻，且較 CRP 更為敏感。SAA 與 CRP 都可作為一種鑑測炎癥的有價值的標誌物[1]，SAA 與CRP 聯閤檢測可以更有效的提高感染性疾病的檢齣率，為臨床醫生提供更敏感的診斷依據。
목적：평고혈청정분양단백A（SAA）여C 반응적단백（CRP）연합검측적림상응용개치。방법채용효체금법화면역산사비탁법대82례감염성질병조（포괄15례폐염、23례급성지기관염、17례급성란미염、16례급성담낭염、11례이선염）환자급92명정상대조조적혈청 SAA 화 CRP 수평진행검측，병비교량자간적농도중위수급각질병조적양성검출솔。결과감염성질병조환자혈청 SAA 여 CRP 농도중위수수평분별위149．50 mg/L、34．20 mg/L，명현고우정상대조조분별위4．60 mg/L、3．82 mg/L，차이유통계학의의（P ＜0．05）；감염성질병조혈청 SAA，여 CRP 양성검출솔분별위87．80％여79．26％。결론감염성질병시，SAA 여 CRP 수평변화추세기본일치，차교 CRP 경위민감。SAA 여 CRP 도가작위일충감측염증적유개치적표지물[1]，SAA 여CRP 연합검측가이경유효적제고감염성질병적검출솔，위림상의생제공경민감적진단의거。
Objective To evaluate the clinical application significance of the combined determination of serum amyloid A (SAA)and C-reactive protein (CRP).Methods The levels of serum SAA and CRP in 82 inflammatory disease patients (1 5 cases of pneumonia,23 cases of acute bronchitis,1 7 cases of acute appendicitis,1 6 cases of acute cholecystitis and 1 1 cases of pancreatitis)and 92 healthy controls were determined by colloidal gold method and immunoturbidimetry, respectively. Their concentration median and positive determination rate were analyzed comparatively between the 2 groups.Results The serum SAA and CRP medians in inflammatory disease group were 1 49.50 mg/L and 34.20 mg/L,respectively,which were obviously higher than those in healthy control group (4.60 mg/L and 3.82 mg/L).There was a statistical significance between the 2 groups (P <0.05).The positive determination rates of serum SAA and CRP in inflammatory disease group were 87.80% and 79.26%,respectively. Conclusions SAA has the same trend with CRP when inflammatory disease happens,and shows a more sensitive performance than CRP.SAA and CRP can be used as meaningful markers for monitoring inflammation.The combined determination of SAA and CRP could improve the determination rate of inflammatory disease,which provides a more sensitive reference for diagnosis.
