CAJ | 학술논문

目的：探讨同型半胱氨酸(HCY)、叶酸(FA)、维生素B6(VitB6)及维生素B12(VitB12)在不同类型糖尿病患者及健康人群中的水平差异和临床意义。方法比较糖尿病合并周围大血管病变组患者15例、糖尿病合并脑梗死组13例、糖尿病合并肾病组23例、糖尿病合并周围神经病变组18例、糖尿病合并视网膜病变组27例、糖尿病无合并症组29例及健康对照组33例的HCY、FA、VitB6及VitB12含量并进行相关分析。结果糖尿病各亚组患者与健康人群组比较, HCY水平明显较高,FA、VitB6、VitB12水平较低,差异有统计学意义(P<0．05),其中糖尿病合并脑梗死组、糖尿病合并周围大血管病变组尤为明显(P<0．01)。糖尿病患者HCY的升高与FA、VitB6、VitB12的降低均具有相关性,差异具有统计学意义(P<0．05),其中糖尿病合并脑梗死组差异尤为显著(P<0．01)。此外,相比未干预组,糖尿病干预组HCY含量较低、FA含量较高,差异具有统计学意义(P<0．05)。结论 HCY、FA、VitB6及VitB12含量与糖尿病及其并发症密切相关,补充FA及VitB12治疗可能有助于改善预后。
목적：탐토동형반광안산(HCY)、협산(FA)、유생소B6(VitB6)급유생소B12(VitB12)재불동류형당뇨병환자급건강인군중적수평차이화림상의의。방법비교당뇨병합병주위대혈관병변조환자15례、당뇨병합병뇌경사조13례、당뇨병합병신병조23례、당뇨병합병주위신경병변조18례、당뇨병합병시망막병변조27례、당뇨병무합병증조29례급건강대조조33례적HCY、FA、VitB6급VitB12함량병진행상관분석。결과당뇨병각아조환자여건강인군조비교, HCY수평명현교고,FA、VitB6、VitB12수평교저,차이유통계학의의(P<0．05),기중당뇨병합병뇌경사조、당뇨병합병주위대혈관병변조우위명현(P<0．01)。당뇨병환자HCY적승고여FA、VitB6、VitB12적강저균구유상관성,차이구유통계학의의(P<0．05),기중당뇨병합병뇌경사조차이우위현저(P<0．01)。차외,상비미간예조,당뇨병간예조HCY함량교저、FA함량교고,차이구유통계학의의(P<0．05)。결론 HCY、FA、VitB6급VitB12함량여당뇨병급기병발증밀절상관,보충FA급VitB12치료가능유조우개선예후。
Objective To explore the clinical significance and compare the difference of homocysteine( HCY)、folic acid (FA)、vitamin B6(VitB6)、vitamin B12(VitB12)levels in kinds of diabetic mellitus(DM)and healthy subjects. Methods Our study is planned to evaluate HCY、FA、VitB6、VitB12 levels in 15 DM cases with peripheral vascular disease、13 DM cases with cerebral infarction、23 DM cases with nephropathy、18 DM cases with peripheral neuropathy、27 DM cases with retinopathy、15 DM cases with peripheral vascular disease、29 DM cases with no complications and 33 healthy subjects. Results HCY levels was found to be significantly higher and FA、VitB6、VitB12 were found to be significantly lower in DM groups than healthy subjects group(P<0. 05),especially in DM with cerebral infarction group or DM with peripheral vascular disease group(P<0. 01). There is a correlation between HCY and FA、VitB6、VitB12 in DM patients either(P<0. 05),especially in DM with cerebral infarction group(P<0. 01). What’s more,HCY levels was lower and FA levels was higher in intervention group when compared with un-in-tervention group. Conclusion The levels of HCY、FA、VitB6、VitB12 were found to be correlated with DM and complications. Sup-plement of FA and VitB12 could play a role in the prognosis of the disease.