CAJ | 학술논문

目的：探讨TBX2、FEZ1在正常胃黏膜、上皮内肿瘤及胃腺癌中的表达及其临床病理意义。方法采用免疫组织化学方法检测30例正常胃黏膜、30例上皮内肿瘤及80例胃腺癌中 TBX、FEZ1蛋白质的表达。应用统计学软件 SPSS15．0分析其与临床病理及预后的关系。结果 TBX2在低分化组织中的阳性表达高于高分化组织（P＜0．05），临床分期Ⅳ期的表达高于Ⅰ期（P＜0．05），肌层浸润＞1/2的表达高于≤1/2的表达（P＜0．05）；FEZ1在低分化组织中的阳性表达低于高分化组织（P＜0．05），临床分期Ⅲ期的阳性率表达低于Ⅰ期的表达（P＜0．05），肿瘤直径＞4cm阳性表达低于≤4cm的表达（P＜0．05），肌层浸润＞1/2的表达低于≤1/2的表达（P＜0．05），有淋巴结转移的表达低于无淋巴结转移的表达（P＜0．05），年龄＞60岁的表达低于≤60岁的表达（P＜0．05）。结论TBX2和 FEZ1在胃黏膜发生发展中发挥着重要作用，前者发挥着原癌基因的作用，后者发挥着抑癌基因的作用。
목적：탐토TBX2、FEZ1재정상위점막、상피내종류급위선암중적표체급기림상병리의의。방법채용면역조직화학방법검측30례정상위점막、30례상피내종류급80례위선암중 TBX、FEZ1단백질적표체。응용통계학연건 SPSS15．0분석기여림상병리급예후적관계。결과 TBX2재저분화조직중적양성표체고우고분화조직（P＜0．05），림상분기Ⅳ기적표체고우Ⅰ기（P＜0．05），기층침윤＞1/2적표체고우≤1/2적표체（P＜0．05）；FEZ1재저분화조직중적양성표체저우고분화조직（P＜0．05），림상분기Ⅲ기적양성솔표체저우Ⅰ기적표체（P＜0．05），종류직경＞4cm양성표체저우≤4cm적표체（P＜0．05），기층침윤＞1/2적표체저우≤1/2적표체（P＜0．05），유림파결전이적표체저우무림파결전이적표체（P＜0．05），년령＞60세적표체저우≤60세적표체（P＜0．05）。결론TBX2화 FEZ1재위점막발생발전중발휘착중요작용，전자발휘착원암기인적작용，후자발휘착억암기인적작용。
Objective To investigate the expression of T-box protein 2 (TBX2)and anti-oncogene FEZ1 in normal gastric muscosa,intraepithelial tumor and gastric adenocarcinoma and the roles of their clinic pathology.Methods The exprssion of TBX2 and FEZ1 were detected by immunohistiochemistry in normal gatromucosa,intraepithelial tumor and gastric carcinoma. Statistic soft ware SPSS1 5 .0 was used to analyze the clinicopathological significance and its relationship to prognosis.Results The positive expression rate of TBX2 protein was higher in low differentiated group than in high differrentiated one (P<0.05),and TBX2 in group with stageⅣwas also higher than in group with stageⅠ(P<0.05),and also in group with over one half deeply muscle infiltration was significantly higher than in group with under one-half infiltration (P<0.05).The positive expression rate of FEZ1 protein was lower in low differentiated group than in high differrentiated one (P<0.05),so was it in group with tumor diameter over 4cm than in group under 4cm (P<0.05 );the expression rate of FEZ1 was lower in group with over 1/2 muscle infiltration than in group with under1/2 infiltrattion,so was it in group with lymph nodule metastasis than in group without lymph nodule metastasis(P<0.05);also it was higher in group with the age over 60 years old than in group under 60 years old (P<0.05).Conclusion TBX2 and FEZ1 were of great importance in the development and prognosis of gastric adenocarcinoma. The former played an important role of oncogene with the latter anti-oncogene.