CAJ | 학술논문

目的：比较干扰素γ释放试验（interferon gamma release assay，IGRA）与结核菌染色涂片、结核菌培养、结核菌素试验（tuberculin skin test，TST）在肺外结核诊断中的敏感性，探讨 IGRA方法在肺外结核中的应用价值。方法采集75例经临床诊断为肺外结核病患者的新鲜外周血，将 IGRA检测结果与传统的检测方法（结核菌染色涂片、结核菌染色涂片培养、TST）的检测结果进行比较。结果75例肺外结核患者中，IGRA检测阳性率为84．0％，结核菌染色涂片（8．0％），结核菌培养（5．3％），TST检测（52．0％），IGRA检测阳性率均明显高于其他临床常用检测方法，差异有统计学意义（P＜0．01）。结论 IGRA试剂检测法诊断肺外结核，敏感性明显高于传统的检测方法，有很好的临床应用价值。
목적：비교간우소γ석방시험（interferon gamma release assay，IGRA）여결핵균염색도편、결핵균배양、결핵균소시험（tuberculin skin test，TST）재폐외결핵진단중적민감성，탐토 IGRA방법재폐외결핵중적응용개치。방법채집75례경림상진단위폐외결핵병환자적신선외주혈，장 IGRA검측결과여전통적검측방법（결핵균염색도편、결핵균염색도편배양、TST）적검측결과진행비교。결과75례폐외결핵환자중，IGRA검측양성솔위84．0％，결핵균염색도편（8．0％），결핵균배양（5．3％），TST검측（52．0％），IGRA검측양성솔균명현고우기타림상상용검측방법，차이유통계학의의（P＜0．01）。결론 IGRA시제검측법진단폐외결핵，민감성명현고우전통적검측방법，유흔호적림상응용개치。
Objective To compare the sensitivity of interferon gamma release test (IGRA) with suptum smear,sputum culture and tuberculin slcintest (TST ) in the diagnosis of extrapulmonary tuberculosis.To investigate the value of IGRA method in extrapulmonary tuberculosis.Methods Fresh peripheral blood samples were collected from 75 patients of clinically diagnosed extrapulmonary tuberculosis.The result was compared with those of traditional gold standard test methods (sputum smear and sputum culture,TST ),and their clinical application value further were analyzed.Results In 75 cases of extrapulmonary tuberculosis,the positive rate by IGRA reagent test was 84.0%,sputum smear 8.0%,sputum culture 5.3%,TST test 52.0%.The positive rate of IGRA was significantly higher than those of other common methods,and the differences were statistically significant (P<0.01).Conclusion In the diagnosis of extrapulmonary tuberculosis,the sensitivity of IGRA reagent is significantly higher than those of the traditional test methods,IGRA has a good clinical value.