CAJ | 학술논문

以2-取代咪唑啉为起始原料,经过磺酰化反应,得到磺酰基咪唑啉2a-2e,然后进行甲基化反应得到1,2,3-三取代咪唑啉碘盐3a-3e。化合物3在室温下经过水解反应或还原反应,可得到两类不同基团N,N,N′-三取代乙二胺衍生物4或5。该反应具有条件温和、副产物少、产物得率高和后处理简单等优点,提供了一种有效的三步合成不同基团N,N,N′-三取代乙二胺衍生物的新方法。所合成产物通过NMR、IR和元素分析方法进行了结构确证。
이2-취대미서람위기시원료,경과광선화반응,득도광선기미서람2a-2e,연후진행갑기화반응득도1,2,3-삼취대미서람전염3a-3e。화합물3재실온하경과수해반응혹환원반응,가득도량류불동기단N,N,N′-삼취대을이알연생물4혹5。해반응구유조건온화、부산물소、산물득솔고화후처리간단등우점,제공료일충유효적삼보합성불동기단N,N,N′-삼취대을이알연생물적신방법。소합성산물통과NMR、IR화원소분석방법진행료결구학증。
Using 2-substituted 4,5-dihydroimidazole as the starting material,arylsulfonyl imidazolines 2a-3e were obtained by the treatment with arylsulfonyl chloride. Then 2a-3e were methylated by iodomethane to afford 1,2,3-trisubstituted imidazolinium io-dides 3a-3e. After hydrolysis reaction or reduction reaction at room temperature,compounds 3 were converted into two types of N, N,N′-trisubstituted ethylenediamine derivative containing different groups. Their structures were confirmed by NMR,IR and elemen-tal analysis. The main advantages of the developed methodology were mild reaction conditions,less byproducts,high yields of prod-ucts and simple work-up procedure. An effective three-step synthesis method of N,N,N′-trisubstituted ethylenediamine derivative containing different groups had been developed.