CAJ | 학술논문

目的：探讨氯吡格雷用于急性非致残性脑血管高危患者的临床价值及用药安全性。方法选取2012年12月～2014年1月我院收治的短暂性脑缺血发作（TIA）和急性缺血性小卒中患者80例，按数字法随机分为对照组与观察组各40例。对照组给予单纯阿司匹林治疗，观察组采取阿司匹林加氯吡格雷联合用药，比较两组患者的临床效果及不良反应发生情况。结果观察组总有效率与对照组相比，差异有统计学意义（P<0.05）；两组患者胃肠道反应、皮肤黏膜出血、皮疹及白细胞减少等不良反应发生率差异无统计学意义（P>0.05）。结论氯吡格雷联合阿司匹林治疗急性非致残性脑血管高危患者的临床疗效显著，明显优于单纯阿司匹林治疗，且可保证用药安全性，值得临床推广使用。
목적：탐토록필격뢰용우급성비치잔성뇌혈관고위환자적림상개치급용약안전성。방법선취2012년12월～2014년1월아원수치적단잠성뇌결혈발작（TIA）화급성결혈성소졸중환자80례，안수자법수궤분위대조조여관찰조각40례。대조조급여단순아사필림치료，관찰조채취아사필림가록필격뢰연합용약，비교량조환자적림상효과급불량반응발생정황。결과관찰조총유효솔여대조조상비，차이유통계학의의（P<0.05）；량조환자위장도반응、피부점막출혈、피진급백세포감소등불량반응발생솔차이무통계학의의（P>0.05）。결론록필격뢰연합아사필림치료급성비치잔성뇌혈관고위환자적림상료효현저，명현우우단순아사필림치료，차가보증용약안전성，치득림상추엄사용。
Objective To investigate the clinical value and safety of clopidogrel in the treatment of a-cute non-disabling cerebral vascular risk patients. Methods 80 patients with transient ischemic attack (TIA) and minor stroke in our hospital from December 2012 to January 2014 were selected as sub-jects. According to figures randomly, all subjects were divided into control group and observation group, each group with 40 cases. The control group was received aspirin alone, aspirin and clopidogrel were received in observation group. The clinical results of the two groups and the incidence of adverse reac-tions were compared. Results The total effective rate was observed and compared, the difference was statistically significant (P<0.05). Incidence of gastrointestinal reactions, skin and mucous membrane bleeding, rash and leukopenia were no significant difference (P>0.05). Conclusion The clinical effi-cacy of clopidogrel and aspirin in the treatment of acute non-disabling cerebral vascular risk patients is significant, significantly better than aspirin. It can ensure safety, be worthy of clinical application.