CAJ | 학술논문

目的：观察粒细胞集落刺激因子（G-CSF）动员内皮祖细胞（EPCs）对心肌梗死患者心功能的影响。方法：收集心肌梗死后心衰患者80例，随机分为常规治疗对照组和粒细胞集落刺激因子（G-CSF）动员治疗观察组，每组40例。 EPCs 使用流式细胞仪检测。结果：观察组治疗前患者 EPCs 比例为（0．11±0．04）％，治疗后 EPCs 比例升高为（5．32±1．06）％（P ＜0．01）。治疗前2组 LVEF、LVEDD 和6MWT 比较差异无显著性（P ＞0．05），治疗后2组上述指标均显著性升高（P ＜0．05和 P ＜0．01），但治疗后上述指标在观察组显著高于对照组（P ＜0．05）。观察组临床治疗有效率为90．0％显著优于对照组的75．0％（P ＜0．05）。对照组和观察组不良反应发生率分别为7．5％和10．0％，两组之间比较差异无显著性（P ＞0．05）。结论：G-CSF 可以高效动员 EPCs，有利于心梗患者心功能的恢复。
목적：관찰립세포집락자격인자（G-CSF）동원내피조세포（EPCs）대심기경사환자심공능적영향。방법：수집심기경사후심쇠환자80례，수궤분위상규치료대조조화립세포집락자격인자（G-CSF）동원치료관찰조，매조40례。 EPCs 사용류식세포의검측。결과：관찰조치료전환자 EPCs 비례위（0．11±0．04）％，치료후 EPCs 비례승고위（5．32±1．06）％（P ＜0．01）。치료전2조 LVEF、LVEDD 화6MWT 비교차이무현저성（P ＞0．05），치료후2조상술지표균현저성승고（P ＜0．05화 P ＜0．01），단치료후상술지표재관찰조현저고우대조조（P ＜0．05）。관찰조림상치료유효솔위90．0％현저우우대조조적75．0％（P ＜0．05）。대조조화관찰조불량반응발생솔분별위7．5％화10．0％，량조지간비교차이무현저성（P ＞0．05）。결론：G-CSF 가이고효동원 EPCs，유리우심경환자심공능적회복。
Objective To observe the effect of motivation of endothelial progenitor cells (EPCs) by granulocyte colony-stimulating factor (G-CSF) on cardiac function in patients with myocardial infarction (MI). Methods Eighty MI patients were sellectedand then were divided into a conventional treatment group (n = 40) and a EPC motivation group (n = 40). EPCs were detected by flow cytometry. Results The rate of EPCs was increased from (0.11 ± 0.04)% in the baseline to (5.32 ± 1.06)% (P < 0.05). Before treatment, 6MWT, LVEF, and LVEDD did not differ significantly between the conventional treatment group and the EPC motivation group (P > 0.05); after treatment, 6MWT, LVEF, and LVEDD were significantly increased in both groups (P < 0.05 and P < 0.01). However, 6MWT, LVEF, and LVEDD were higher in the EPC motivation group than in the conventional treatment group (P <0.05). The clinical effectiveness rate was higher in the EPC motivation group than in the conventional treatment group (90.0% vs. 75.0%, P < 0.05). There was no significant difference between the two groups in adverse reactions (7.5%vs. 10.0%, P > 0.05). Conclusions G-CSF can markedly motivate EPCs, which is beneficial for improvement of cardiac function in MI patients.