CAJ | 학술논문

目的：探讨骨桥蛋白（OPN）、环氧化酶-2（COX-2）和细胞周期素 D1（CyclinD1）在乳腺浸润癌中的表达及其与临床病理特征的关系。方法：采用免疫组化法检测70例乳腺浸润癌标本中三者的表达情况，并分析三者间的关系及其与临床病理特征的关系。结果：≤45岁和＞45岁患者 OPN 阳性表达率分别为78．8％和73．0％；肿块直径≤3 cm 和＞3 cm 者阳性表达率分别为79．3％和73．2％；Ⅰ、Ⅱ、Ⅲ级浸润癌者阳性表达率分别为77．8％、73．8％和78．9％，组间差异均无统计学意义（P ＞0．05）。在无、有淋巴结转移组中 OPN 阳性率分别为62．5％和93．3％；在Ⅰ～Ⅱ、Ⅲ～Ⅳ期浸润癌中 OPN 的阳性表达率分别为68．0％和95．0％，差异均有统计学意义（P ＜0．05）；OPN 与 ER、PR 负相关，与 CerbB2、COX-2、CyclinD1表达正相关。结论：OPN 在乳腺癌的侵袭、转移过程中起重要作用，COX-2、CyclinD1可能为其协同分子。
목적：탐토골교단백（OPN）、배양화매-2（COX-2）화세포주기소 D1（CyclinD1）재유선침윤암중적표체급기여림상병리특정적관계。방법：채용면역조화법검측70례유선침윤암표본중삼자적표체정황，병분석삼자간적관계급기여림상병리특정적관계。결과：≤45세화＞45세환자 OPN 양성표체솔분별위78．8％화73．0％；종괴직경≤3 cm 화＞3 cm 자양성표체솔분별위79．3％화73．2％；Ⅰ、Ⅱ、Ⅲ급침윤암자양성표체솔분별위77．8％、73．8％화78．9％，조간차이균무통계학의의（P ＞0．05）。재무、유림파결전이조중 OPN 양성솔분별위62．5％화93．3％；재Ⅰ～Ⅱ、Ⅲ～Ⅳ기침윤암중 OPN 적양성표체솔분별위68．0％화95．0％，차이균유통계학의의（P ＜0．05）；OPN 여 ER、PR 부상관，여 CerbB2、COX-2、CyclinD1표체정상관。결론：OPN 재유선암적침습、전이과정중기중요작용，COX-2、CyclinD1가능위기협동분자。
Objective To observe the expressions of OPN, COX-2 and CyclinD1 in breast infiltrating carcinoma and evaluate their relationships with clinic pathological features. Methods Expression of the above three indexes were detected from 70 breast cancinoma patients by immunohistochemistry. The relationships among them and clinicopathological features were analyzed. Results The positive expression rates of OPN were 78.8% in cases (≤45 years old) and 73.0% in cases (> 45 years old); the positive expression rates were 79.3%(tumor diameter ≤ 3 cm) and 73.2% (tumor diameter > 3 cm); the positive expression rates were 77.8%, 73.8% and 78.9% in cases ofⅠgrade, Ⅱgrade and Ⅲ respectively, the positive rates had no statistical significances(P > 0.05). The expression rates of OPN in cases of breast infiltrating carcinoma without and with axillary node metastasis were 62.5% and 93.3%, in cases at stage Ⅰ~Ⅱ and Ⅲ ~Ⅳ were, 68.0% and 95.0% respectively, the positive rates had statistical significances(P < 0.05). The expression of OPN was negatively correlated with ER and PR while positively correlated with CerbB2, COX-2 and CyclinD1. Conclusions OPN plays an important role in the invasion and metastasis of breast carcinoma coordinated with COX-2 and CyclinD1.