CAJ | 학술논문

目的：探讨食管鳞癌患者血清 IL-23和 MMP-9的表达水平以及两者的相关性和临床意义。方法：选取经病理确诊的食管鳞癌患者48例和同期胃镜活检结果良性的体检者30例。采用酶联免疫吸附法（ELISA）检测两组血清 IL-23和 MMP-9的表达水平，并进一步分析两者的相关性。结果：鳞癌组血清IL-23和 MMP-9表达水平均高于对照组（t ＝26．66，16．89，P ＜0．05），且血清 IL-23和 MMP-9的表达呈正相关关系（r ＝0．790，P ＜0．05），血清 IL-23表达水平与 TNM 分期、淋巴结有无转移和分化程度（高、中分化与低分化）有关，P 值分别为0．040、0．042和0．038。结论： IL-23的高表达与食管鳞癌的发生发展密切相关。IL-23可能通过上调 MMP-9的表达参与食管鳞癌的侵袭与转移。
목적：탐토식관린암환자혈청 IL-23화 MMP-9적표체수평이급량자적상관성화림상의의。방법：선취경병리학진적식관린암환자48례화동기위경활검결과량성적체검자30례。채용매련면역흡부법（ELISA）검측량조혈청 IL-23화 MMP-9적표체수평，병진일보분석량자적상관성。결과：린암조혈청IL-23화 MMP-9표체수평균고우대조조（t ＝26．66，16．89，P ＜0．05），차혈청 IL-23화 MMP-9적표체정정상관관계（r ＝0．790，P ＜0．05），혈청 IL-23표체수평여 TNM 분기、림파결유무전이화분화정도（고、중분화여저분화）유관，P 치분별위0．040、0．042화0．038。결론： IL-23적고표체여식관린암적발생발전밀절상관。IL-23가능통과상조 MMP-9적표체삼여식관린암적침습여전이。
Objective To investigate the relationship of the serum level of IL-23 and MMP-9 with the clinicopathologic features in patients with esophageal squamous cell carcinoma (ESCC). Methods 48 pathologically confirmed ESCC patients and 30 Endoscopic biopsy of benign were included in this study. The serum levels of IL-23 and MMP-9 were examined by enzyme-linked immunosorbent assay (ELISA). Results Serum IL-23 level in patients with ESCC was significantly higher than that in controls (t = 26.66, 16.89, P<0.05). Furthermore, Pearson′s correlation analysis revealed that serum IL-23 was positively correlated with the serum MMP-9 level in ESCC patients (r = 0.790, P < 0.05). Statistical analysis showed that enhanced serum IL-23 significantly correlated with the degree of differentiation and lymph node metastasis. Conclusion Overexpression of IL-23 may involve in the occurrence and development of ESCC. IL-23 may contribute to tumorinvasion and metastasis by stimulating the expression of MMP-9.