河北医药
河北醫藥
하북의약
HEBEI MEDICAL JOURNAL
2014年
21期
3205-3208
,共4页
张剑虹%张飞%张晓丽%张凡%刘博
張劍虹%張飛%張曉麗%張凡%劉博
장검홍%장비%장효려%장범%류박
趋化因子受体%PTEN%组织芯片%结肠黏液腺癌
趨化因子受體%PTEN%組織芯片%結腸黏液腺癌
추화인자수체%PTEN%조직심편%결장점액선암
chemokine receptor%PTEN%tissue chip%colon mucinous adenocarcinoma
目的:探讨趋化因子受体CXCR4和PTEN蛋白在结肠黏液腺癌中的表达及其与癌转移及预后的关系。方法采用免疫组织化学及组织芯片技术,检测25例结肠正常组织、92例大肠黏液腺癌组织及癌旁组织中PTEN蛋白和趋化因子受体CXCR4的表达情况,并与临床资料对比分析。结果 PTEN 蛋白在结肠黏液腺癌的表达率为31.52%(29/92),在癌组织和癌旁组织的表达率明显低于正常结肠组织,差异有统计学意义( P <0.05);趋化因子受体CXCR4在结肠黏液腺癌的表达率为61.95%(579/2),在癌组织和癌旁组织的表达率明显高于正常结肠组织,差异有统计学意义( P <0.01)。 PTEN蛋白、CXCR4与肿瘤浸润深度、淋巴结转移和临床分期显著相关( P<0.05)。结论趋化因子受体CXCR4和PTEN蛋白的过表达与结肠癌的浸润、转移相关,且它们在其浸润转移中具有相关性,常态化检测有利与结肠黏液腺癌的治疗。
目的:探討趨化因子受體CXCR4和PTEN蛋白在結腸黏液腺癌中的錶達及其與癌轉移及預後的關繫。方法採用免疫組織化學及組織芯片技術,檢測25例結腸正常組織、92例大腸黏液腺癌組織及癌徬組織中PTEN蛋白和趨化因子受體CXCR4的錶達情況,併與臨床資料對比分析。結果 PTEN 蛋白在結腸黏液腺癌的錶達率為31.52%(29/92),在癌組織和癌徬組織的錶達率明顯低于正常結腸組織,差異有統計學意義( P <0.05);趨化因子受體CXCR4在結腸黏液腺癌的錶達率為61.95%(579/2),在癌組織和癌徬組織的錶達率明顯高于正常結腸組織,差異有統計學意義( P <0.01)。 PTEN蛋白、CXCR4與腫瘤浸潤深度、淋巴結轉移和臨床分期顯著相關( P<0.05)。結論趨化因子受體CXCR4和PTEN蛋白的過錶達與結腸癌的浸潤、轉移相關,且它們在其浸潤轉移中具有相關性,常態化檢測有利與結腸黏液腺癌的治療。
목적:탐토추화인자수체CXCR4화PTEN단백재결장점액선암중적표체급기여암전이급예후적관계。방법채용면역조직화학급조직심편기술,검측25례결장정상조직、92례대장점액선암조직급암방조직중PTEN단백화추화인자수체CXCR4적표체정황,병여림상자료대비분석。결과 PTEN 단백재결장점액선암적표체솔위31.52%(29/92),재암조직화암방조직적표체솔명현저우정상결장조직,차이유통계학의의( P <0.05);추화인자수체CXCR4재결장점액선암적표체솔위61.95%(579/2),재암조직화암방조직적표체솔명현고우정상결장조직,차이유통계학의의( P <0.01)。 PTEN단백、CXCR4여종류침윤심도、림파결전이화림상분기현저상관( P<0.05)。결론추화인자수체CXCR4화PTEN단백적과표체여결장암적침윤、전이상관,차타문재기침윤전이중구유상관성,상태화검측유리여결장점액선암적치료。
Objective To investigate the expression and clinical significance of chemokine receptor-CXCR4,PTEN in colon mucinous adenocarcinoma and to explore the correlation between their expression and cancer invasion,metastasis as well as patient’ s prognosis.Methods The expression levels of PTEN protein and CXCR4 were detected by immunohistochemistry in 20 cases of normal colon tissues, 92 cases of colorectal mucinous adenocarcinoma and the tissues beside cancer.The detection results were contrastively analyzed with clinical data.Results The positive expression rate of PTEN protein in colon mucinous adenocarcinoma was 31.52%(29/92),which in cancer tissue and the tissues beside cancer was significantly lower than that in normal colon tissue ( P<0.05).The positive expression rate of CXCR4 in colon mucinous adenocarcinoma was 61.95%(57/92),which in cancer tissue and the tissues beside cancer was significantly higher than that in normal colon tissue ( P <0.01) .The expressions of PTEN protein and CXCR4 were closely correlated to the infiltration depth of cancer,lymph node metastasis and tumor staging( P <0.05).C onclusion The overexpression of chemokine receptor CXCR4 and PTEN protein are closely related to invasion,metastasis of colon carcinoma,so routine detection of chemokine receptor CXCR4 and PTEN protein is helpful for the treatment of colon mucinous adenocarcinoma.