CAJ | 학술논문

目的：分析胆汁中CEA和CA199水平对诊断胆囊癌的临床价值。方法收集我院2012年6月至2013年6月期间诊治的胆囊癌患者45例设为观察组，另选同期的45例胆囊良性病变（胆囊息肉和胆囊结石）患者设为对照组，两组患者均实施血清肿瘤标志物（CEA和CA199）检测，对比分析两组患者的检测结果。结果研究结果显示，观察组患者血清和胆汁CEA水平以及CA199均显著高于对照组（P＜0.05）；同时，观察组胆汁CEA水平和CA199显著高于血清CEA水平及CA199水平CA199（P＜0.05）；观察组Ⅰ期，Ⅱ期，Ⅲ期胆汁中CA199、CEA与血清CA199、CEA比较，胆汁中CA199、CEA水平较血清水平差异显著（P＜0.05），表达敏感性更高，且胆囊癌的分期与胆汁中CA19-9、CEA浓度呈正相关关系。结论通过检测胆汁中CEA和CA199水平能有效的鉴别胆囊癌和胆囊良性病变，具有非常重要的临床价值，同时，胆汁中CEA、CA19-9水平对于诊断胆囊癌价值优于血清，值得在临床应用上推广。
목적：분석담즙중CEA화CA199수평대진단담낭암적림상개치。방법수집아원2012년6월지2013년6월기간진치적담낭암환자45례설위관찰조，령선동기적45례담낭량성병변（담낭식육화담낭결석）환자설위대조조，량조환자균실시혈청종류표지물（CEA화CA199）검측，대비분석량조환자적검측결과。결과연구결과현시，관찰조환자혈청화담즙CEA수평이급CA199균현저고우대조조（P＜0.05）；동시，관찰조담즙CEA수평화CA199현저고우혈청CEA수평급CA199수평CA199（P＜0.05）；관찰조Ⅰ기，Ⅱ기，Ⅲ기담즙중CA199、CEA여혈청CA199、CEA비교，담즙중CA199、CEA수평교혈청수평차이현저（P＜0.05），표체민감성경고，차담낭암적분기여담즙중CA19-9、CEA농도정정상관관계。결론통과검측담즙중CEA화CA199수평능유효적감별담낭암화담낭량성병변，구유비상중요적림상개치，동시，담즙중CEA、CA19-9수평대우진단담낭암개치우우혈청，치득재림상응용상추엄。
Objective To analyze the clinical value of CEA and CA199 levels in bile for diagnosis of gallbladder carcinoma. Methods In our hospital from June2012 to June 2013 year during the diagnosis and treatment of gallbladder carcinoma were 45 cases for the observation group, another 45 cases of the same period(benign lesions of the gallbladder gallbladder polyps and gallstone) were set as control group. Results The results showed that serum and bile CEA and CA199 levels in patients in the observation group were significantly higher(P<0.05); while the observation group bile CEA and CA199 levels were significantly higher than the level of serum CEA levels and CA199 CA199(P<0.05); observation groupⅠ, Ⅱ, Ⅲ of bile CA199, CEA compared with serum CA199, CEA, bile CA199, CEA serum levels were significantly higher than the difference(P<0.05), the expression of a higher sensitivity, and gallbladder staging and bile CA19-9, CEA concentrations were positively correlated. Conclusion The level of CEA and CA199 detection of bile can effectively distinguish malignant and benign lesion of gallbladder, clinical value, very important also, bile CEA, CA19-9 level in serum value than the diagnosis of gallbladder carcinoma, is worthy to be popularized in clinical application.