CAJ | 학술논문

目的：回顾性分析食管癌同步放化疗结果，提高个体化治疗的认识。方法分析本院2005年1月至2007年12月收治的60例食管癌患者的临床资料。结果1、3、5年生存率分别为58.3%、33.3%和23.3%。完全缓解组和部分缓解组的生存曲线有显著差异（χ2=10.76， P=0.0010）；无缓解者均在1年死亡。蕈伞型组和髓质型组的1、3、5年生存曲线有显著差异（χ2=4.78，P=0.0288）；缩窄型及溃疡型在1年内病死率为87.5%，无长期生存。食管癌上、中及下三段的1、3、5年生存曲线无明显差异（χ2=3.96，P=0.1379）。二维与三维技术放疗1、3、5年的生存曲线无差异（χ2＝0.02，P=0.8759）。食管癌死亡原因主要为局部未控和局部复发占73.9%。结论食管癌同步放化疗是种有效治疗方法，其疗效与其个体敏感性相关，制定个体化疗模式，有可能进一步提高疗效。
목적：회고성분석식관암동보방화료결과，제고개체화치료적인식。방법분석본원2005년1월지2007년12월수치적60례식관암환자적림상자료。결과1、3、5년생존솔분별위58.3%、33.3%화23.3%。완전완해조화부분완해조적생존곡선유현저차이（χ2=10.76， P=0.0010）；무완해자균재1년사망。심산형조화수질형조적1、3、5년생존곡선유현저차이（χ2=4.78，P=0.0288）；축착형급궤양형재1년내병사솔위87.5%，무장기생존。식관암상、중급하삼단적1、3、5년생존곡선무명현차이（χ2=3.96，P=0.1379）。이유여삼유기술방료1、3、5년적생존곡선무차이（χ2＝0.02，P=0.8759）。식관암사망원인주요위국부미공화국부복발점73.9%。결론식관암동보방화료시충유효치료방법，기료효여기개체민감성상관，제정개체화료모식，유가능진일보제고료효。
Objective Results of synchronous chemotherapy and radiotherapy on esophageal carcinoma were retrospectively analyzed for raising awareness of individualized treatment. Methods Clinical information of 60 cases with esophageal carcinoma admitted to our hospital from January 2005 to December 2007 was analyzed. Results Survival rates of 1 year, 3 years, 5 years were 58.3%, 33.3% and 23.3% respectively. There was significant difference in the survival curves of complete response group and partial response group(χ2=10.76, P=0.0010); Those without any mitigation all died within one year. There was significant difference in the survival curves of fungating type group and medulla type group among 1 year, 3 years, 5 years(χ2=4.78, P=0.0288); the mortality rate of sclerotic type and ulcer type within one year was 87.5%, no long-term survival. There was no significant difference in the survival curves of upper, middle and lower three sections of esophageal carcinoma among 1 year, 3 years, 5 years(χ2=3.96, P=0.1379). Besides, there was no significant difference in the survival curves of two-dimension and three-dimension technologies among 1 year, 3 years, 5 years(χ2=0.02, P=0.8759). The main causes of mortality were local uncontrolled and local recurrence, accounting for 73.9%. Conclusion Synchronous chemotherapy and radiotherapy was effective in the treatment of esophageal carcinoma, its efficacy associated with individual sensitivity. Developing individual chemotherapy models made it possible to further enhance the effect.