浙江临床医学
浙江臨床醫學
절강림상의학
ZHEJIANG CLINICAL MEDICAL JOURNAL
2014年
10期
1532-1533
,共2页
心脏型脂肪酸结合蛋白%缺血修饰白蛋白%急性心肌梗死
心髒型脂肪痠結閤蛋白%缺血脩飾白蛋白%急性心肌梗死
심장형지방산결합단백%결혈수식백단백%급성심기경사
heart-type fatty acid-binding protein%Ischemia-modified albumin%Acute myocardial infarction
目的：探讨心脏型脂肪酸结合蛋白（H-FABP）、缺血修饰蛋白（IMA）联合肌酸激酶同工酶MB（CK-MB）和肌钙蛋白I（cTnI）在急性心肌梗死（AMI）早期诊断中的应用价值。方法采用免疫层析法检测H-FABP和cTnI、白蛋白-钴离子结合试验检测IMA、免疫透射比浊法检测CK-MB。结果 AMI发病3h时的H-FABP、IMA、CK-MB和CTnI的阳性率分别为82.4%、75.0%、29.4%和20.6%，6h时分别为92.6%、85.3%、64.7%和48.5%，9h时分别为60.3%、67.6%、80.9%和75.0%；AMI发病3~6 h时H-FABP和IMA检出率高，9h以后CK-MB和CTnI检出率高；四项联合检测，灵敏性、特异性、阳性预测值及阴性预测值达95.6%、96.0%、98.5%和88.9%。结论 H-FABP和IMA在早期诊断AMI中有重要临床意义，四项联合检测可以提高早期诊断率。
目的：探討心髒型脂肪痠結閤蛋白（H-FABP）、缺血脩飾蛋白（IMA）聯閤肌痠激酶同工酶MB（CK-MB）和肌鈣蛋白I（cTnI）在急性心肌梗死（AMI）早期診斷中的應用價值。方法採用免疫層析法檢測H-FABP和cTnI、白蛋白-鈷離子結閤試驗檢測IMA、免疫透射比濁法檢測CK-MB。結果 AMI髮病3h時的H-FABP、IMA、CK-MB和CTnI的暘性率分彆為82.4%、75.0%、29.4%和20.6%，6h時分彆為92.6%、85.3%、64.7%和48.5%，9h時分彆為60.3%、67.6%、80.9%和75.0%；AMI髮病3~6 h時H-FABP和IMA檢齣率高，9h以後CK-MB和CTnI檢齣率高；四項聯閤檢測，靈敏性、特異性、暘性預測值及陰性預測值達95.6%、96.0%、98.5%和88.9%。結論 H-FABP和IMA在早期診斷AMI中有重要臨床意義，四項聯閤檢測可以提高早期診斷率。
목적：탐토심장형지방산결합단백（H-FABP）、결혈수식단백（IMA）연합기산격매동공매MB（CK-MB）화기개단백I（cTnI）재급성심기경사（AMI）조기진단중적응용개치。방법채용면역층석법검측H-FABP화cTnI、백단백-고리자결합시험검측IMA、면역투사비탁법검측CK-MB。결과 AMI발병3h시적H-FABP、IMA、CK-MB화CTnI적양성솔분별위82.4%、75.0%、29.4%화20.6%，6h시분별위92.6%、85.3%、64.7%화48.5%，9h시분별위60.3%、67.6%、80.9%화75.0%；AMI발병3~6 h시H-FABP화IMA검출솔고，9h이후CK-MB화CTnI검출솔고；사항연합검측，령민성、특이성、양성예측치급음성예측치체95.6%、96.0%、98.5%화88.9%。결론 H-FABP화IMA재조기진단AMI중유중요림상의의，사항연합검측가이제고조기진단솔。
Objective To explore the value of joint detection H-FABP,IMA,CK-MB and cTnI in diagnosis of acute myocardial infarction. Methods H-FABP and cTnI were detected by immune chromatography,IMA was detected by albumincobaltions combined,CK-MB was detected by immune transmission turbidimetry. Results The sensitivity value were 82.4%75.0% 29.4% and 20.6% for H-FABP、IMA、CK-MB and CTnI at 3 hours,that were 92.6%、85.3%、64.7 % and 48.5% at 6 hours,that were 60.3%、67.6%、80.9%and 75.0%at 9 hours. It was high detection rate of H-FABP and IMA in 3~6h,it was high detection rate of CK-MB and CTnI after 9h. The sensitivity,specificity,positive predictive value and negative predictive value in AMI diagnosis were 95.6%、96.0%、98.5%and 88.9%. Conclusion H-FABP and IMA have important clinical significance in early diagnosis of AMI.Four joint detection can improve the detection rate and reduce the misdiagnosis and missed diagnosis.
