CAJ | 학술논문

目的：初步探讨角叉菜胶致急性炎性痛大鼠机械痛阈（ Mechanical Withdrawal Threshold， MWTs）与局部皮肤血流灌注量（ Blood Perfusion， BP）的相关性。方法20只雄性Sprague-Dawley（ SD）大鼠随机分为正常对照组和模型组。采用足底注射角叉菜胶建立大鼠急性炎性痛模型，观察两组大鼠在造模前、造模后4 h、24 h、48 h、72 h患侧的MWTs和BP，并比较分析两种行为学的相关性。结果与正常对照组相比，模型组大鼠造模后足跖MWTs明显下降（P＜0.01），BP明显增加（P＜0.01）。两者做相关性分析发现，大鼠患侧足跖MWTs和BP呈负相关，在造模后4 h和造模后72 h有显著差异（ P＜0.01）。结论角叉菜胶致急性炎性痛大鼠有显著的机械痛阈和局部皮肤血流灌注量改变，这两种变化在发生发展中呈负相关。
목적：초보탐토각차채효치급성염성통대서궤계통역（ Mechanical Withdrawal Threshold， MWTs）여국부피부혈류관주량（ Blood Perfusion， BP）적상관성。방법20지웅성Sprague-Dawley（ SD）대서수궤분위정상대조조화모형조。채용족저주사각차채효건립대서급성염성통모형，관찰량조대서재조모전、조모후4 h、24 h、48 h、72 h환측적MWTs화BP，병비교분석량충행위학적상관성。결과여정상대조조상비，모형조대서조모후족척MWTs명현하강（P＜0.01），BP명현증가（P＜0.01）。량자주상관성분석발현，대서환측족척MWTs화BP정부상관，재조모후4 h화조모후72 h유현저차이（ P＜0.01）。결론각차채효치급성염성통대서유현저적궤계통역화국부피부혈류관주량개변，저량충변화재발생발전중정부상관。
Objective To explore the relationship between mechanical withdrawal threshold ( MWTs) and local cutaneous blood perfusion ( BP ) in rats with acute inflammation induced by carrageenan.Methods Twenty male Sprague-Dawley ( SD) rats were randomly divided into control and model groups.The acute inflammatory rat model was established by subcutaneously injecting with carrageenan into the left hindpaw.MWTs were measured by Dynamic Plantar Aesthesiometer 37450 before injection ( as base) of carrageenan and at 4 h, 24 h, 48 h, 72 h after carrageenan injection. The local cutaneous BP was detected by Pericam Perfusion Speckle Imager ( Pericam PSI) at the time after measuring of MWTs.The above two behaviors were compared and the relationship between them was analyzed.Results MWTs of the model group rats were decreased while BP significantly increased than that in the control group ( P<0.01 ) .The MWTs and BP in the model rats showed a negative correlation, especially the correlation index showed significant differences at 4 h and 72 h after carrageenan injection ( P<0.01) .Conclusions Carrageenan-induced acute inflammation in rats causes significant changes in mechanical pain threshold, which has a negative correlation with local cutaneous blood perfusion.