CAJ | 학술논문

在高脂饮食诱导肥胖过程中，大量促炎性细胞浸润到脂肪组织，分泌促炎性因子引起慢性炎性，导致胰岛素抵抗，最终引起2型糖尿病和心血管疾病等慢性疾病的发生。肥大细胞作为一种重要固有免疫细胞，参与调控了饮食诱导肥胖及上述相关疾病的发生，而通过遗传缺失或药物稳定肥大细胞，可以改善小鼠中高脂饮食诱导的肥胖和胰岛素抵抗。因此，肥大细胞是潜在的治疗肥胖及相关代谢疾病的重要靶点。天然黄酮类化合物木犀草素，是一种高效的肥大细胞稳定剂，通过饮食添加木犀草素可以抑制高脂饮食诱导小鼠体重的增加和胰岛素抵抗的形成。本文综述了肥胖相关的免疫调控、肥大细胞在饮食诱导肥胖中的作用和木犀草素等天然肥大细胞稳定剂改善肥胖及其相关代谢疾病等方面的研究进展。
재고지음식유도비반과정중，대량촉염성세포침윤도지방조직，분비촉염성인자인기만성염성，도치이도소저항，최종인기2형당뇨병화심혈관질병등만성질병적발생。비대세포작위일충중요고유면역세포，삼여조공료음식유도비반급상술상관질병적발생，이통과유전결실혹약물은정비대세포，가이개선소서중고지음식유도적비반화이도소저항。인차，비대세포시잠재적치료비반급상관대사질병적중요파점。천연황동류화합물목서초소，시일충고효적비대세포은정제，통과음식첨가목서초소가이억제고지음식유도소서체중적증가화이도소저항적형성。본문종술료비반상관적면역조공、비대세포재음식유도비반중적작용화목서초소등천연비대세포은정제개선비반급기상관대사질병등방면적연구진전。
Diet-induced obesity is associated with a chronic state of low-grade inflammation with progres-sive pro-inflammatory immune cells recruitment into adipose tissue. Immune cell-and adipose cell-derived adipokines augment adipose tissue inflammation and consequentially induce insulin resistance and obesi-ty-related metabolic complications. As an innate cell, mast cell has been involved in the development of obesity and its associated diseases. Genetic deficiency and pharmacological stabilization of mast cells protect mice from diet-induced obesity and diabetes. Therefore, mast cell may be an important target for the treatment of obesity. Luteolin, a natural flavonoid, is an efficient mast cell stabilizer. Diet supplement of luteolin ameliorates diet-induced obesity and insulin resistance in mice. This review focuses on the role of mast cell and other im-mune cells in obesity and associated metabolic diseases andsuggests utilizing natural mast cell stabilizer lute-olin and quercetin as a new therapeutic and interventional approach for these diseases.