CAJ | 학술논문

目的：探索中药汤剂安全性主动监测方法，并对含黄连的中药汤剂进行安全性主动监测，了解含中药黄连的汤剂不良反应发生情况和不良反应特征。方法：以访谈方式，对使用含黄连的中药汤剂的门诊患者进行用药调查，记录患者一般资料以及不良反应发生情况，计量资料用Excel表进行统计分析。结果：使用含黄连的中药汤剂的201例患者中，不良反应发生率为8．95％（18/201）。排便次数增多10例，便秘4例，恶心反胃4例，但症状较轻微，均未影响药物继续治疗。其不良反应发生与用药剂量、患者体质、药物配伍密切相关。结论：本项研究探讨了中药汤剂不良反应与患者体质寒热虚实、药物配伍的关系，为探讨中药不良反应发生规律、探讨符合中医药特点的不良反应监测方法提出了新思路。
목적：탐색중약탕제안전성주동감측방법，병대함황련적중약탕제진행안전성주동감측，료해함중약황련적탕제불량반응발생정황화불량반응특정。방법：이방담방식，대사용함황련적중약탕제적문진환자진행용약조사，기록환자일반자료이급불량반응발생정황，계량자료용Excel표진행통계분석。결과：사용함황련적중약탕제적201례환자중，불량반응발생솔위8．95％（18/201）。배편차수증다10례，편비4례，악심반위4례，단증상교경미，균미영향약물계속치료。기불량반응발생여용약제량、환자체질、약물배오밀절상관。결론：본항연구탐토료중약탕제불량반응여환자체질한열허실、약물배오적관계，위탐토중약불량반응발생규률、탐토부합중의약특점적불량반응감측방법제출료신사로。
Objective:To explore the active monitoring method on the safety of traditional Chinese medicine decoction,and discuss the occurrence characters of the adverse drug reactions ( ADR) of decoction containing Coptis.Methods:Patients who were prescribed the Traditional Chinese medicine decoction containing Coptis were interviewed,and the common data and the ADR characteristics were col-lected.All the data were analyzed with Excellsoftware.Results:Among the 201 patients who were followed up,8.95%(1 8/201)presen-ted with ADR,which included 10cases of defecate number increase,4 cases of constipation,and 4 cases of nausea.But the treatment con-tinued because of the slight symptom.And the ADR rate of Coptis was closely connected with the dose,the medical compatibility,and the patient's condition.Conclusion:This study explores the relationship between the ADR and the medical compatibility,as well as the heat-cold,deficiency-excess condition of patients.It points out a new way to study the rules of the occurrence,and the monitoring method of the ADR,which is in accordance with the characteristics of traditional Chinese medicine.