CAJ | 학술논문

目的：观察益气清肺汤联合化疗治疗老年晚期非小细胞肺癌对患者生活质量的影响。方法：将63例患者随机分为治疗组33例与对照组30例，2组均采用相同化疗方案治疗；21 d为1个周期，2个周期评价疗效。治疗组在化疗前2 d加用益气清肺汤治疗。观察2组治疗后中医临床证候变化、治疗前后生活质量量表EORTC－QLQ－SF－36调查问卷评价及不良反应。结果：2组中医临床证候变化比较，治疗组与对照组总改善率分别为84．8％和60．0％（ P＜0．05）；2组治疗前后生活质量量表EORTC－QLQ－SF－36调查问卷评分比较，治疗组躯体功能、角色功能、情绪功能、物理症状及整体健康状况均优于对照组，差异有统计学意义（P＜0．05）；而认知功能、社会功能差异无统计学意义（P＞0．05）。2组不良反应比较，治疗组低于对照组（P＞0．05）。结论：益气清肺汤联合化疗治疗老年晚期非小细胞肺癌具有改善中医临床证候，减轻不良反应，提高生活质量，延长生存期。
목적：관찰익기청폐탕연합화료치료노년만기비소세포폐암대환자생활질량적영향。방법：장63례환자수궤분위치료조33례여대조조30례，2조균채용상동화료방안치료；21 d위1개주기，2개주기평개료효。치료조재화료전2 d가용익기청폐탕치료。관찰2조치료후중의림상증후변화、치료전후생활질량량표EORTC－QLQ－SF－36조사문권평개급불량반응。결과：2조중의림상증후변화비교，치료조여대조조총개선솔분별위84．8％화60．0％（ P＜0．05）；2조치료전후생활질량량표EORTC－QLQ－SF－36조사문권평분비교，치료조구체공능、각색공능、정서공능、물리증상급정체건강상황균우우대조조，차이유통계학의의（P＜0．05）；이인지공능、사회공능차이무통계학의의（P＞0．05）。2조불량반응비교，치료조저우대조조（P＞0．05）。결론：익기청폐탕연합화료치료노년만기비소세포폐암구유개선중의림상증후，감경불량반응，제고생활질량，연장생존기。
Objective:To observe the impacts of yiqi qingfei decoction combined with chemotherapy on life quality of the elderly patients with late stage of non-small cell lung cancer ( NSCLC) .Methods:Sixty-three patients were randomly divided into treatment group ( n=33) and control group (n=30).Patients in both groups were given chemotherapy, and one treatment course was 21 day.Evaluations were given after 2 treatment courses.Patients in the treatment group were given Yiqi Qingfei decoction 2 days before the chemotherapy. The change of TCM clinical syndromes, the evaluation and adverse reactions, as well as quality of life questionnaire EORTC-QLQ-SF-36 were observed before and after treatment among patients in both groups.Results:In terms of the change of TCM clinical syndromes, the total improvement rates of the treatment group and the control group were respectively 84.8%and 60.0%(P<0.05).As for the quali-ty of life scale EORTC-QLQ-SF-36 questionnaire scores of patients in the two groups after treatment, the physical function, role func-tion, emotional function, physical symptoms and overall health status of patients in treatment group were all better than those of the con-trol group(P<0.05).There was no significant difference in terms of the cognitive function and social function between the two groups(P>0.05).The incidence of the adverse reactions in the treatment group was lower than that of the control group(P>0.05).Conclusion:The combined therapy of Yiqi Qingfei decoction and chemotherapy treating elderly patients with non-small cell lung cancer at the late stage can improve TCM clinical syndromes, reduce adverse reactions, improve quality of life and prolong survival.