CAJ | 학술논문

采用气相色谱法测定2，3-二羟基-1，8-桉树脑在不同有机溶剂中的溶解度及在有机溶剂/水两相体系中的分配比，为设计该化合物的萃取分离工艺提供依据。结果表明：2，3-二羟基-1，8-桉树脑易溶于水、二氯甲烷和三氯甲烷，可溶于乙酸乙酯、1，2-二氯乙烷和α-蒎烯（25℃时的溶解度分别为26.1 g·L-1、24.9 g·L-1和14.9 g·L-1），难溶于石油醚、环己烷等非极性有机溶剂；有机溶剂种类、温度、油水体积比对分配比有较大的影响；以二氯甲烷和三氯甲烷为有机溶剂，在温度为35℃、油水体积比为1.0的条件下，2，3-二羟基-1，8-桉树脑的分配比分别为16.3和10.3。
채용기상색보법측정2，3-이간기-1，8-안수뇌재불동유궤용제중적용해도급재유궤용제/수량상체계중적분배비，위설계해화합물적췌취분리공예제공의거。결과표명：2，3-이간기-1，8-안수뇌역용우수、이록갑완화삼록갑완，가용우을산을지、1，2-이록을완화α-파희（25℃시적용해도분별위26.1 g·L-1、24.9 g·L-1화14.9 g·L-1），난용우석유미、배기완등비겁성유궤용제；유궤용제충류、온도、유수체적비대분배비유교대적영향；이이록갑완화삼록갑완위유궤용제，재온도위35℃、유수체적비위1.0적조건하，2，3-이간기-1，8-안수뇌적분배비분별위16.3화10.3。
To provide a process for separating 2,3-dihydroxy-1,8-cineole from aqueous solution by solvent extraction method,the solubility of 2,3-dihydroxy-1,8-cineole in different organic solvents and its distribution ratio in organic-aqueous biphasic system were measured by gas chromatography.Results showed that 2,3-di-hydroxy-1 ,8-cineole was freely soluble in water,dichloromethane and chloroform;soluble in ethyl acetate,1 ,2-dichloroethane andα-pinene,the solubility at 25 ℃ were 26.1 g·L-1,24.9 g·L-1 and 14.9 g·L-1,respec-tively;hardly soluble in non-polar organic solvents such as petroleum ether and cyclohexane.The organic sol-vent type,temperature and volume ratio of organic solvent to water had obvious effect on distribution ratio of 2, 3-dihydroxy-1 ,8-cineole.Using dichloromethane or chloroform as organic solvent,when the temperature was 35 ℃,the volume ratio of organic solvent to water was 1.0,the distribution ratio of 2,3-dihydroxy-1,8-cineole were 16.3 and 10.3,respectively.