风湿病与关节炎
風濕病與關節炎
풍습병여관절염
Rheumatism and Arthritis
2014年
10期
27-29
,共3页
周定华%周正球%吴炅%金艳%黄佳珉
週定華%週正毬%吳炅%金豔%黃佳珉
주정화%주정구%오경%금염%황가민
关节炎,类风湿%三军丸%中西医结合疗法
關節炎,類風濕%三軍汍%中西醫結閤療法
관절염,류풍습%삼군환%중서의결합요법
arthritis,rheumatoid%Sanjun Pill%therapy of combining traditional Chinese and Western Medicine
目的:观察三军丸联合美洛昔康及甲氨蝶呤治疗类风湿关节炎的临床疗效。方法:将62例类风湿关节炎患者随机分为治疗组和对照组,每组31例。对照组予美洛昔康每次7.5 mg,每日2次,甲氨蝶呤每次10 mg,每周1次,口服。治疗组在对照组基础上加用三军丸每次8~10丸,每日2次,口服。观察两组治疗前后临床症状、体征指标及急性炎症指标等,采用疾病活动性评分(DAS28)标准为临床疗效评价指标,并观察不良反应。结果:治疗组显效10例,进步11例,有效5例,无效4例,有效率占86.67%;对照组显效8例,进步10例,有效5例,无效7例,有效率占76.67%。两组疗效比较,差异有统计学意义(P<0.05)。治疗后,治疗组临床症状、体征指标及DAS28评分、急性炎症指标较治疗前均有改善,差异有统计学意义(P<0.05或P<0.01);其中,关节压痛数、晨僵时间、VAS评分及红细胞沉降率与对照组比较,差异有统计学意义(P <0.05).结论:三军丸联合美洛昔康及甲氨蝶呤治疗类风湿关节炎有较好疗效。
目的:觀察三軍汍聯閤美洛昔康及甲氨蝶呤治療類風濕關節炎的臨床療效。方法:將62例類風濕關節炎患者隨機分為治療組和對照組,每組31例。對照組予美洛昔康每次7.5 mg,每日2次,甲氨蝶呤每次10 mg,每週1次,口服。治療組在對照組基礎上加用三軍汍每次8~10汍,每日2次,口服。觀察兩組治療前後臨床癥狀、體徵指標及急性炎癥指標等,採用疾病活動性評分(DAS28)標準為臨床療效評價指標,併觀察不良反應。結果:治療組顯效10例,進步11例,有效5例,無效4例,有效率佔86.67%;對照組顯效8例,進步10例,有效5例,無效7例,有效率佔76.67%。兩組療效比較,差異有統計學意義(P<0.05)。治療後,治療組臨床癥狀、體徵指標及DAS28評分、急性炎癥指標較治療前均有改善,差異有統計學意義(P<0.05或P<0.01);其中,關節壓痛數、晨僵時間、VAS評分及紅細胞沉降率與對照組比較,差異有統計學意義(P <0.05).結論:三軍汍聯閤美洛昔康及甲氨蝶呤治療類風濕關節炎有較好療效。
목적:관찰삼군환연합미락석강급갑안접령치료류풍습관절염적림상료효。방법:장62례류풍습관절염환자수궤분위치료조화대조조,매조31례。대조조여미락석강매차7.5 mg,매일2차,갑안접령매차10 mg,매주1차,구복。치료조재대조조기출상가용삼군환매차8~10환,매일2차,구복。관찰량조치료전후림상증상、체정지표급급성염증지표등,채용질병활동성평분(DAS28)표준위림상료효평개지표,병관찰불량반응。결과:치료조현효10례,진보11례,유효5례,무효4례,유효솔점86.67%;대조조현효8례,진보10례,유효5례,무효7례,유효솔점76.67%。량조료효비교,차이유통계학의의(P<0.05)。치료후,치료조림상증상、체정지표급DAS28평분、급성염증지표교치료전균유개선,차이유통계학의의(P<0.05혹P<0.01);기중,관절압통수、신강시간、VAS평분급홍세포침강솔여대조조비교,차이유통계학의의(P <0.05).결론:삼군환연합미락석강급갑안접령치료류풍습관절염유교호료효。
Objective:To observe the clinical curative effect ofSanjun Pill combined with meloxicam and methotrexate in the treatment of rheumatoid arthritis.Methods:62 cases of rheumatoid arthritis were randomly and equally divided into a treatment group and a control group.The control group was treated orally with meloxicam, 7.5 mg each time,twice a day,and methotrexate,10 mg each time,once a week.The treatment group was orally given Sanjun Pill based on the treatment of the control group,8 ~ 10 pills each time,twice a day.The two groups were observed before and after treatment on the aspects of clinical symptoms,signs,indexes and acute inflammation index.The disease activity score standard(DAS28) was used as the clinical efficacy evaluation index,observing the adverse reactions.Results:In the treatment group,10 cases were remarkably effective,11 cases were improved, 5 cases were effective,4 cases were invalid,the effective rate accounting for 86.67%;while in the control group, 8 cases were markedly effective,10 cases were improved,5 cases were effective,and 7 cases were invalid,the efifciency accounting for 76.67%.The difference of the efifcacy between the two groups was statistically signiifcant(P< 0.05). After treatment,the clinical symptoms,signs index,DAS28 score,and acute inlfammation index were improved than those before the treatment,the difference being statistically signiifcant(P< 0.05 orP< 0.01);the differences of clinical symptoms and signs,tender joint count,time of morning stiffness,VAS score,acute inlfammation indexes and erythrocyte sedimentation rate between the two groups were statistical significant(P< 0.05).Conclusion:There are good curative effects ofSanjun Pill combined with methotrexate and meloxicam in the treatment of rheumatoid arthritis.