CAJ | 학술논문

目的：探讨养血祛风方对大鼠空间学习记忆能力的改善作用。方法采用亚氨基二丙腈腹腔注射制造抽动障碍大鼠模型，将造模成功的大鼠随机分为模型组、西药组及中药低、中、高剂量组，各给药组给予相应药物灌胃，正常组和模型组给予等量生理盐水灌胃，连续8周。造模后第1、4、8周分别进行旷场分析及水迷宫实验，评价各组大鼠空间学习记忆能力。结果与正常组比较，模型组跨格次数增加，垂直活动次数明显减少；与模型组比较，各给药组垂直活动次数增加；第4、8周中药中、高剂量组模型大鼠逃避潜伏期明显缩短(P＜0.05)。结论养血祛风方中、高剂量有改善慢性抽动障碍大鼠学习记忆能力的作用。
목적：탐토양혈거풍방대대서공간학습기억능력적개선작용。방법채용아안기이병정복강주사제조추동장애대서모형，장조모성공적대서수궤분위모형조、서약조급중약저、중、고제량조，각급약조급여상응약물관위，정상조화모형조급여등량생리염수관위，련속8주。조모후제1、4、8주분별진행광장분석급수미궁실험，평개각조대서공간학습기억능력。결과여정상조비교，모형조과격차수증가，수직활동차수명현감소；여모형조비교，각급약조수직활동차수증가；제4、8주중약중、고제량조모형대서도피잠복기명현축단(P＜0.05)。결론양혈거풍방중、고제량유개선만성추동장애대서학습기억능력적작용。
Objective To observe the effects of blood nourishing and wind expel formulae on learning and memory capabilities of rats with tic disorders. Methods Intradialytic Parenteral Nutrition peritoneal injection was used to establish the rat model of tic disorders. The successful test subjects were categorized into 5 different groups, namely the model group, the Chinese medicine groups (low dosage, medium dosage and high dosage) and the western medicine group. The test groups were each given gastric perfusion of the related medicine, whereas the control and model groups were each given equal amounts of saline solution continuously for 8 weeks. Open field test and water maze test were carried out in the 1st, 4th and 8th weeks to evalute the learning and memory capabilities. Results In comparison with the control group, the model group showed obvious increase in movement across grid and decrease in vertical locomotion. Statistical significance was obtained showing an increase in vertical locomotion in the treatment groups compared with the model group. In the Chinese medicine groups, the medium and high dosage groups exhibited shorter escape latency and increased exploratory behavior (P<0.05) in the 4th and 8th weeks. Conclusion Among the blood nourishing and wind expel formula, the medium and high dosage showed ameliorating effects on the memory and learning capabilities of rats with tic disorders.