中国中医药信息杂志
中國中醫藥信息雜誌
중국중의약신식잡지
CHINESE JOURNAL OF INFORMATION ON TRADITIONAL CHINESE MEDICINE
2014年
11期
24-26,27
,共4页
青黛%桥本甲状腺炎%甲状腺球蛋白抗体%甲状腺过氧化物酶抗体%中医药疗法
青黛%橋本甲狀腺炎%甲狀腺毬蛋白抗體%甲狀腺過氧化物酶抗體%中醫藥療法
청대%교본갑상선염%갑상선구단백항체%갑상선과양화물매항체%중의약요법
indigo naturalis%Hashimoto's thyroiditis%thyroglobulin antibody%thyroid peroxidase antibody%traditional Chinese medicine therapy
目的：观察外用青黛对桥本甲状腺炎(HT)血清中甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)的影响。方法将65例HT患者随机分为治疗组33例和对照组32例。2组甲状腺功能亢进、甲状腺功能减退者分别予甲巯咪唑片10 mg/d、左旋甲状腺素片25～50μg/d控制甲状腺功能,稳定2周后,治疗组在此基础上于颈前甲状腺投射区域局部外敷青黛治疗,疗程6个月。结果中医临床证候2组均有改善,组间比较差异有统计学意义(P＜0.05,P＜0.01)。治疗组中医证候疗效为81.82%(27/33),对照组为65.63%(21/32),2组比较差异有统计学意义(P＜0.01)。治疗组临床疗效总有效率为84.85%(28/33),对照组为71.88%(23/32),2组比较差异有统计学意义(P＜0.05)。治疗组治疗后血清 TGAb、TPOAb 水平较治疗前下降(P＜0.05),2组比较差异有统计学意义(P＜0.01)。结论外用青黛治疗HT可提高疗效,并能有效降低甲状腺自身免疫性抗体指标。
目的：觀察外用青黛對橋本甲狀腺炎(HT)血清中甲狀腺毬蛋白抗體(TGAb)、甲狀腺過氧化物酶抗體(TPOAb)的影響。方法將65例HT患者隨機分為治療組33例和對照組32例。2組甲狀腺功能亢進、甲狀腺功能減退者分彆予甲巰咪唑片10 mg/d、左鏇甲狀腺素片25～50μg/d控製甲狀腺功能,穩定2週後,治療組在此基礎上于頸前甲狀腺投射區域跼部外敷青黛治療,療程6箇月。結果中醫臨床證候2組均有改善,組間比較差異有統計學意義(P＜0.05,P＜0.01)。治療組中醫證候療效為81.82%(27/33),對照組為65.63%(21/32),2組比較差異有統計學意義(P＜0.01)。治療組臨床療效總有效率為84.85%(28/33),對照組為71.88%(23/32),2組比較差異有統計學意義(P＜0.05)。治療組治療後血清 TGAb、TPOAb 水平較治療前下降(P＜0.05),2組比較差異有統計學意義(P＜0.01)。結論外用青黛治療HT可提高療效,併能有效降低甲狀腺自身免疫性抗體指標。
목적：관찰외용청대대교본갑상선염(HT)혈청중갑상선구단백항체(TGAb)、갑상선과양화물매항체(TPOAb)적영향。방법장65례HT환자수궤분위치료조33례화대조조32례。2조갑상선공능항진、갑상선공능감퇴자분별여갑구미서편10 mg/d、좌선갑상선소편25～50μg/d공제갑상선공능,은정2주후,치료조재차기출상우경전갑상선투사구역국부외부청대치료,료정6개월。결과중의림상증후2조균유개선,조간비교차이유통계학의의(P＜0.05,P＜0.01)。치료조중의증후료효위81.82%(27/33),대조조위65.63%(21/32),2조비교차이유통계학의의(P＜0.01)。치료조림상료효총유효솔위84.85%(28/33),대조조위71.88%(23/32),2조비교차이유통계학의의(P＜0.05)。치료조치료후혈청 TGAb、TPOAb 수평교치료전하강(P＜0.05),2조비교차이유통계학의의(P＜0.01)。결론외용청대치료HT가제고료효,병능유효강저갑상선자신면역성항체지표。
Objective To observe the efficacy of topical indigo naturalis on the serum thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) in Hashimoto's thyroiditis (HT). Methods Sixty-five cases of HT were randomly divided into the treatment group (33 cases) and the control group (32 cases). Hyperthyroidism patients and hypothyroidism patients in the two groups were treated with methimazole 10 mg/d and levothyrocine 25-50 μg/d to control their thyroid function. Based on the basic treatment, patients in the treatment group were treated with topical indigo naturalis local external application, which lasted for 6 months. Results TCM clinical symptoms were improved in both two groups, with statistical significance between the two groups (P<0.05, P<0.01). The efficacy of TCM clinical symptoms was 81.82% (27/33) in the treatment group and 65.63% (21/32) in the control group, with statistical significance (P<0.01). The total effective rate of the treatment group was 84.85% (28/33) and the control group was 71.88%(23/32), with statistical significance between the two groups (P<0.05). Compared with that before treatment, the levels of TGAb and TPOAb were lower in both groups (P<0.05), and with statistical significance between the two groups (P<0.01). Conclusion Indigo naturalis can improve efficacy of treatment for HT, and effectively reduce autoimmune antibodies indicators of thyroid.
