中国老年学杂志
中國老年學雜誌
중국노년학잡지
CHINESE JOURNAL OF GERONTOLOGY
2014年
20期
5637-5639
,共3页
史洁%王英%谷田正弘%尹明星%王静%耿同超%酒谷薰%左焕琮
史潔%王英%穀田正弘%尹明星%王靜%耿同超%酒穀薰%左煥琮
사길%왕영%곡전정홍%윤명성%왕정%경동초%주곡훈%좌환종
近红外光学成像技术%额极%工作记忆%老化
近紅外光學成像技術%額極%工作記憶%老化
근홍외광학성상기술%액겁%공작기억%노화
Near-infrared spectroscopy%Frontal pole%Working memory%Aging
目的:使用近红外光学成像技术研究增龄对额极皮层在工作记忆中激活的影响。方法青年组女性健康被试8人、中年组女性健康被试7人参加本研究,两组被试进行斯腾伯格项目再认任务,使用近红外光学成像技术监测任务期间双侧额极区的血流动力学变化,计算额极区氧合血红蛋白的偏侧指数并进行统计学分析。结果青年组和中年组相比斯腾伯格任务的低记忆负荷和高记忆负荷任务的正确率无统计学差异(P>0.05)。在低记忆负荷任务中两组的反应时间无统计学差异;而在高记忆负荷任务中,中年被试的反应时间显著长于青年组(P<0.05)。青年组额极激活表现为右侧优势,而中年组表现为双侧激活反应( P<0.05)。结论本研究结果支持额极功能随着老化过程发生改变,而且随老化出现的前额叶( PFC)偏侧性减弱的HAROLD模型早在中年阶段就可表现出来。
目的:使用近紅外光學成像技術研究增齡對額極皮層在工作記憶中激活的影響。方法青年組女性健康被試8人、中年組女性健康被試7人參加本研究,兩組被試進行斯騰伯格項目再認任務,使用近紅外光學成像技術鑑測任務期間雙側額極區的血流動力學變化,計算額極區氧閤血紅蛋白的偏側指數併進行統計學分析。結果青年組和中年組相比斯騰伯格任務的低記憶負荷和高記憶負荷任務的正確率無統計學差異(P>0.05)。在低記憶負荷任務中兩組的反應時間無統計學差異;而在高記憶負荷任務中,中年被試的反應時間顯著長于青年組(P<0.05)。青年組額極激活錶現為右側優勢,而中年組錶現為雙側激活反應( P<0.05)。結論本研究結果支持額極功能隨著老化過程髮生改變,而且隨老化齣現的前額葉( PFC)偏側性減弱的HAROLD模型早在中年階段就可錶現齣來。
목적:사용근홍외광학성상기술연구증령대액겁피층재공작기억중격활적영향。방법청년조녀성건강피시8인、중년조녀성건강피시7인삼가본연구,량조피시진행사등백격항목재인임무,사용근홍외광학성상기술감측임무기간쌍측액겁구적혈류동역학변화,계산액겁구양합혈홍단백적편측지수병진행통계학분석。결과청년조화중년조상비사등백격임무적저기억부하화고기억부하임무적정학솔무통계학차이(P>0.05)。재저기억부하임무중량조적반응시간무통계학차이;이재고기억부하임무중,중년피시적반응시간현저장우청년조(P<0.05)。청년조액겁격활표현위우측우세,이중년조표현위쌍측격활반응( P<0.05)。결론본연구결과지지액겁공능수착노화과정발생개변,이차수노화출현적전액협( PFC)편측성감약적HAROLD모형조재중년계단취가표현출래。
Objective To employ near-infrared spectroscopy(NIRS) to measure frontal pole activity while younger and older sub-jects performed a working memory( WM〗) task.Mte hods 8 healthy younger and 7 healthy older women subjects were recruited.All subjects were performed a Sternberg′s itemr-ecognition task in which the memory -set size varied between 1 and 6 digits.NIRS was used to measure frontal pole activity, laterality index were calculated.Results During Sternberg′s task, the accuracy of low and high memory-load between younger and older groups had no differences.However, in high memory-load tasks, older subjects performed slower than younger subjects ( P<00.5 ) .Younger subjects showed right lateral responses with a stronger right than left activation in the frontal pole, whereas older sub-jects showed bilateral-responses( P<00.5 ) .Conclusions The laterality in frontal pole activity changes with aging, which is consistent with the HAROLD model.Working memory task causes asymmetrical frontal pole activation in younger adults, while older adults tends to the re-duced hemispheric lateralization, which suggest HAROLD pattern develops before old age.