中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2014年
28期
258-261,263
,共5页
潘博%潘敏求%黎月恒%李东芳%李琳霈
潘博%潘敏求%黎月恆%李東芳%李琳霈
반박%반민구%려월항%리동방%리림패
肺癌%养阴清解法则%肺复方%中药治疗%临床实验研究
肺癌%養陰清解法則%肺複方%中藥治療%臨床實驗研究
폐암%양음청해법칙%폐복방%중약치료%림상실험연구
Lung cancer%Nourishing yin and clearing method%Lung compound prescription%Chinese medicine treatment%Clinical and experimental study
目的：主要观察养阴清解法则治疗肺癌的临床疗效。方法采用单盲随机对照方法，对符合纳入标准的原发性非小细胞肺癌80例，分为治疗组（养阴清解法则组成的“肺复方组”）与对照组（化瘀清解法则组成的“化瘀方组”）各40例进行对照研究，1个月为1个疗程，连续治疗2个疗程，观察并随访记录两组临床症状，瘤体疗效、疾病进展时间，中位生存期，生存率及生活质量、体质量等变化情况，并进行抑瘤作用和提高免疫功能作用的动物实验研究。结果临床研究瘤体有效率（CR+PR）治疗组15.00%，明显高于对照组7.50%（P＜0.05），瘤体稳定率（CR+PR+SD）治疗组87.50%，明显高于对照组67.50%（P＜0.05）。疾病进展时间（TTP）治疗组6.6个月，对照组5.4个月。中位生存期（MST）治疗组13.6个月，对照组11.4个月；1、2年生存率治疗组分别为77.50%、55.00%，高于对照组60.00%、40.00%（P＜0.05）；临床症状总有效率，治疗组87.50%高于对照组67.00%，（P＜0.05）；同时生活质量改善、体质量改善，治疗组均优于对照组（P＜0.05）。实验研究：养阴清解法则对Lius肺癌的抑瘤率为34.8%，对S180实体瘤抑瘤率30.5%，均优于化瘀清解法则（分别为20.7%、17.7%）（P＜0.05）。养阴清解法则对EAC（艾氏腹水瘤）和H22（肝癌）的抑制作用优于化瘀清解法则（P＜0.05）。对免疫功能影响：养阴清解法则对小鼠IL-2（白细胞介素-2）活性、迟发型超敏反应、网状内皮系统吞噬功能和血清溶血素形成均有明显作用，其作用强度均高于化瘀清解法则（P＜0.05）。结论养阴清解法则（该法则组成的“肺复方”）具有益气养阴、清热解毒之功，作为基本法则治疗肺癌，十分切合肺癌的病因病机，其改善肺癌患者临床症状，提高生活质量，抑制、稳定瘤体，提高机体免疫功能，延缓疾病进展及延长生存期的作用均得到临床和实验的证实，提示养阴清解法则及该法则组成的肺复方是治疗肺癌的有效治则和方药。
目的：主要觀察養陰清解法則治療肺癌的臨床療效。方法採用單盲隨機對照方法，對符閤納入標準的原髮性非小細胞肺癌80例，分為治療組（養陰清解法則組成的“肺複方組”）與對照組（化瘀清解法則組成的“化瘀方組”）各40例進行對照研究，1箇月為1箇療程，連續治療2箇療程，觀察併隨訪記錄兩組臨床癥狀，瘤體療效、疾病進展時間，中位生存期，生存率及生活質量、體質量等變化情況，併進行抑瘤作用和提高免疫功能作用的動物實驗研究。結果臨床研究瘤體有效率（CR+PR）治療組15.00%，明顯高于對照組7.50%（P＜0.05），瘤體穩定率（CR+PR+SD）治療組87.50%，明顯高于對照組67.50%（P＜0.05）。疾病進展時間（TTP）治療組6.6箇月，對照組5.4箇月。中位生存期（MST）治療組13.6箇月，對照組11.4箇月；1、2年生存率治療組分彆為77.50%、55.00%，高于對照組60.00%、40.00%（P＜0.05）；臨床癥狀總有效率，治療組87.50%高于對照組67.00%，（P＜0.05）；同時生活質量改善、體質量改善，治療組均優于對照組（P＜0.05）。實驗研究：養陰清解法則對Lius肺癌的抑瘤率為34.8%，對S180實體瘤抑瘤率30.5%，均優于化瘀清解法則（分彆為20.7%、17.7%）（P＜0.05）。養陰清解法則對EAC（艾氏腹水瘤）和H22（肝癌）的抑製作用優于化瘀清解法則（P＜0.05）。對免疫功能影響：養陰清解法則對小鼠IL-2（白細胞介素-2）活性、遲髮型超敏反應、網狀內皮繫統吞噬功能和血清溶血素形成均有明顯作用，其作用彊度均高于化瘀清解法則（P＜0.05）。結論養陰清解法則（該法則組成的“肺複方”）具有益氣養陰、清熱解毒之功，作為基本法則治療肺癌，十分切閤肺癌的病因病機，其改善肺癌患者臨床癥狀，提高生活質量，抑製、穩定瘤體，提高機體免疫功能，延緩疾病進展及延長生存期的作用均得到臨床和實驗的證實，提示養陰清解法則及該法則組成的肺複方是治療肺癌的有效治則和方藥。
목적：주요관찰양음청해법칙치료폐암적림상료효。방법채용단맹수궤대조방법，대부합납입표준적원발성비소세포폐암80례，분위치료조（양음청해법칙조성적“폐복방조”）여대조조（화어청해법칙조성적“화어방조”）각40례진행대조연구，1개월위1개료정，련속치료2개료정，관찰병수방기록량조림상증상，류체료효、질병진전시간，중위생존기，생존솔급생활질량、체질량등변화정황，병진행억류작용화제고면역공능작용적동물실험연구。결과림상연구류체유효솔（CR+PR）치료조15.00%，명현고우대조조7.50%（P＜0.05），류체은정솔（CR+PR+SD）치료조87.50%，명현고우대조조67.50%（P＜0.05）。질병진전시간（TTP）치료조6.6개월，대조조5.4개월。중위생존기（MST）치료조13.6개월，대조조11.4개월；1、2년생존솔치료조분별위77.50%、55.00%，고우대조조60.00%、40.00%（P＜0.05）；림상증상총유효솔，치료조87.50%고우대조조67.00%，（P＜0.05）；동시생활질량개선、체질량개선，치료조균우우대조조（P＜0.05）。실험연구：양음청해법칙대Lius폐암적억류솔위34.8%，대S180실체류억류솔30.5%，균우우화어청해법칙（분별위20.7%、17.7%）（P＜0.05）。양음청해법칙대EAC（애씨복수류）화H22（간암）적억제작용우우화어청해법칙（P＜0.05）。대면역공능영향：양음청해법칙대소서IL-2（백세포개소-2）활성、지발형초민반응、망상내피계통탄서공능화혈청용혈소형성균유명현작용，기작용강도균고우화어청해법칙（P＜0.05）。결론양음청해법칙（해법칙조성적“폐복방”）구유익기양음、청열해독지공，작위기본법칙치료폐암，십분절합폐암적병인병궤，기개선폐암환자림상증상，제고생활질량，억제、은정류체，제고궤체면역공능，연완질병진전급연장생존기적작용균득도림상화실험적증실，제시양음청해법칙급해법칙조성적폐복방시치료폐암적유효치칙화방약。
Objective To observe the clinical therapeutic effects of Nourishing yin and clearing method for non-small cell lung cancer.Methods By using randomized single blind controlled method, 80 cases of patient were selected according to the selecting standard and divided into experimental group and control group randomLy which both had 40 cases respectively. One month a course of treatment. Clinical symptoms, tumor state, time to disease progression, median survival time, survival rate and quality of life, weight were observed and recorded in two courses of treatment. Animal experimental study on the antitumor effect and improve immune function was done as well.Results Clinical study The tumor with efficiency (CR+PR)the treatment group was 15.00%,significantly higher than control group 7.50%(P<0.05).The tumor body stable rate (CR+PR+SD)the treatment group was 87.50%, significantly higher than control group67.50%(P<0.05). TTP the treatment group was 6.6months, the control group was 5.4months. The one year and tow year survival rate were 77.50%、55.00% respectively, higher than control group 60%, 40.00%(P<0.05).The total efficiency of clinical effective the treatment group was 87.50%, higher than control group 67.00%(P<0.05).Experimental group ′s quality of life and weight were also improved significantly. Experimental Study :Nourishing yin and clearing method on Lius lung cancer tumor inhibition rate was 34.8%, solid tumor inhibition rate was 30.5%, better than removing blood stasis and clearing method (20.7%, 17.7%)(P<0.05). To the inhibition on EAC and H22 Nourishing yin and clearing method is better than removing blood stasis and clearing method (P<0.05). The effects on the immune function: Nourishing yin and clearing method has obvious effect on mice IL-2 activity, delayed type hypersensitivity, the reticuloendothelial system phagocytic function and serum hemolysin formation, much better than removing blood stasis and clearing method.Conclusions Nourishing yin and clearing method has the function of supplementing qi and nourishing Yin, clearing heat and detoxification. As the basic rule in the treatment of lung cancer is very suitable for the etiology and pathogenesis of lung cancer. Nourishing yin and clearing method can significantly relieve the main clinical symptoms, increase the quality of life, restrain and stabilize tumor size, improve immune function, delay the progression of the disease, prolong the survival period which were confirmed in clinical and experimental study. Prompt that nourishing yin and clearing method and lung compound prescription is effective therapy and prescription for treatment of lung cancer .
