CAJ | 학술논문

目的：探讨口腔鳞状细胞癌中Paxillin和MMP-9的表达及其临床意义。方法：采用免疫组织化学-SP法检测55例口腔鳞状细胞癌组织中Paxillin和MMP-9的表达,用Spearman秩相关分析两者之间的相关,用χ2检验分析Paxillin和MMP-9表达与临床病理参数的关联。结果：(1)本实验结果显示,Paxillin表达在癌细胞质和/或胞膜,呈棕黄色。55例口腔鳞状细胞癌中阳性率为67.27%(37/55)。 MMP-9主要表达在癌细胞质内,少量有细胞膜表达,呈黄色。55例口腔鳞状细胞癌中阳性率为65.45%(36/55)。(2)Spearman秩相关分析结果显示,在口腔鳞状细胞癌中Paxillin和MMP-9表达呈正相关,关系系数为：rs=0.349,P<0.05。(3) Paxillin和MMP-9表达率均与淋巴结转移有关,Paxillin表达与肿瘤的分化程度有关,与临床分期、年龄、性别无显著关联。结论：(1)Paxillin和MMP-9在淋巴结转移组中的表达率均显著高于无淋巴结转移组,提示Paxillin和MMP-9表达可能与口腔癌的侵袭转移生物学行为有关联。(2) Paxillin和MMP-9在口腔癌呈正相关,从该结果可推测在口腔癌的发生发展过程中二者在某一信号通路上具有协同作用。
목적：탐토구강린상세포암중Paxillin화MMP-9적표체급기림상의의。방법：채용면역조직화학-SP법검측55례구강린상세포암조직중Paxillin화MMP-9적표체,용Spearman질상관분석량자지간적상관,용χ2검험분석Paxillin화MMP-9표체여림상병리삼수적관련。결과：(1)본실험결과현시,Paxillin표체재암세포질화/혹포막,정종황색。55례구강린상세포암중양성솔위67.27%(37/55)。 MMP-9주요표체재암세포질내,소량유세포막표체,정황색。55례구강린상세포암중양성솔위65.45%(36/55)。(2)Spearman질상관분석결과현시,재구강린상세포암중Paxillin화MMP-9표체정정상관,관계계수위：rs=0.349,P<0.05。(3) Paxillin화MMP-9표체솔균여림파결전이유관,Paxillin표체여종류적분화정도유관,여림상분기、년령、성별무현저관련。결론：(1)Paxillin화MMP-9재림파결전이조중적표체솔균현저고우무림파결전이조,제시Paxillin화MMP-9표체가능여구강암적침습전이생물학행위유관련。(2) Paxillin화MMP-9재구강암정정상관,종해결과가추측재구강암적발생발전과정중이자재모일신호통로상구유협동작용。
Objective:In a variety of human tumors, cell adhesion molecule Paxillin is closely related to tumor invasion and metastasis. The study was to detect Paxillin expression in oral squamous cell carcinoma and its relationship with clinicopathological parameters associated with the expression of MMP-9. Explore of Paxillin and oral cancer lymph node metastasis. Methods:The expressions of Paxillin and MMP-9 were detected by S-P Immunohistochemical method in 55 cases oral squamous cell carcinoma,χ2 test analysis of Paxillin and MMP-9 expression with clinicopathological parameters associated,Spearman rank correlation analysis. Results:1. immunohistochemistry results showed that, Paxillin expression in oral squamous cell carcinoma of the quality of cancer cells and/or cell membrane,brownish yellow. 55 patients with oral squamous cell carcinoma,the positive expression rate 67. 27%(37/55). MMP-9 is mainly expressed in cancer cell quality,a small amount of membrane ex-pression,yellow. 55 patients with oral squamous cell carcinoma,the positive expression rate 65. 45%(36/55). 2. Spearman rank correlation analysis results show Paxillin and the expression of MMP-9 in oral squamous cell carcinoma was positive correlation,the correlation coefficient:rs=0. 349,P<0. 05. 3 . Paxillin and MMP-9 expression rate of lymph node metastasis Paxillin to the expression of tumor dif-ferentiation,no significant association between Clinical Stage,age,gender. Conclusion:1. Paxillin and MMP-9 in lymph node metastasis in the positive rate was significantly higher than that without lymph node metastasis,suggesting Paxillin and MMP-9 expression may be associated with oral cancer invasion and metastasis biological behavior. 2. Paxillin and MMP-9 was positively correlated with oral cancer, can be inferred from the results of both oral cancer development has a synergistic effect on a signaling pathway.