CAJ | 학술논문

非酒精性脂肪肝（NAFLD）是一种比较常见的慢性肝病，其涵盖范围包括脂肪肝、脂肪性肝炎以及肝硬化。其发病率的增加与肥胖、2型糖尿病等密切相关。越来越多人体试验表明，肠道微生物菌群过度生长与 NAFLD 和非酒精性脂肪肝炎（NASH）有关。最近，已有很多研究表明益生菌在改善 NAFLD 方面有效，已被视为一种治疗 NAFLD 的新方式，但仍需大样本试验和较长周期的临床随访进行深入研究。鉴于此，本文主要对 NAFLD 以及益生菌治疗 NAFLD 的动物实验和临床试验研究进展情况进行综述，从而进一步为益生菌用于 NAFLD 的治疗提供借鉴。
비주정성지방간（NAFLD）시일충비교상견적만성간병，기함개범위포괄지방간、지방성간염이급간경화。기발병솔적증가여비반、2형당뇨병등밀절상관。월래월다인체시험표명，장도미생물균군과도생장여 NAFLD 화비주정성지방간염（NASH）유관。최근，이유흔다연구표명익생균재개선 NAFLD 방면유효，이피시위일충치료 NAFLD 적신방식，단잉수대양본시험화교장주기적림상수방진행심입연구。감우차，본문주요대 NAFLD 이급익생균치료 NAFLD 적동물실험화림상시험연구진전정황진행종술，종이진일보위익생균용우 NAFLD 적치료제공차감。
Non-alcoholic fatty liver disease (NAFLD)is a common chronic liver disease. It covers a spectrum of liver diseases that range from hepatic steatosis to steatohepatitis and cirrhosis. The increase in its prevalence is linked to obesity and type 2 diabetes. More evidence shows a relation between overgrowth of gut microbiota with NAFLD and non-alcoholic steatohepatitis (NASH). Recently,many studies indicate that probiotics have very good effcts on improving NAFLD. Probiotics have been seen as a new way of treating NAFLD. But probiotics as treatment of NAFLD still need substantiation through more trials with a larger sample size and with longer-term clinical follow-up. Therefore,the research progress in probiotics treatment on animal experiments and clinical trials in NAFLD is reviewed in order to further understand the role of probiotics treatment,and provide the basis for the treatment of NAFLD.