CAJ | 학술논문

海洋天然产物是当前国际上一个生机勃勃的热点研究领域，其对恶性肿瘤、心脑血管疾病等人类重大常见疾病均具有较好的预防和治疗作用，已成为发现先导药物的重要源泉。目前，海洋天然产物在治疗代谢综合征相关疾病方面应用的基础研究也逐渐深入，发现了许多具有良好效果的新天然产物，新的药效机制不断被阐明，研究层面逐步扩大，研究成果丰硕。本文对2010年后发表的海洋天然产物在防治代谢综合征相关疾病，如中心性肥胖、胰岛素抵抗、高脂血症、高血压、炎症等方面的研究进行综述。
해양천연산물시당전국제상일개생궤발발적열점연구영역，기대악성종류、심뇌혈관질병등인류중대상견질병균구유교호적예방화치료작용，이성위발현선도약물적중요원천。목전，해양천연산물재치료대사종합정상관질병방면응용적기출연구야축점심입，발현료허다구유량호효과적신천연산물，신적약효궤제불단피천명，연구층면축보확대，연구성과봉석。본문대2010년후발표적해양천연산물재방치대사종합정상관질병，여중심성비반、이도소저항、고지혈증、고혈압、염증등방면적연구진행종술。
Studying on marine natural products is a vibrant research area in the world. Due to their prevention and treatment effects on malignant tumor,cardiovascular disease and other major human diseases,marine natural products have become an important guidance to find the primary drugs. Recently,beneficial effects of marine natural products on treatment of metabolic syndrome related diseases have been intensively explored. Therefore,numbers of novel active products were found out and new mechanisms were revealed. This article reviews the research literature published after 2010 and summarizes the effects of marine natural products in metabolic syndrome related diseases,such as central obesity,insulin resistance,hyperlipidemia,hypertension and inflammation.