CAJ | 학술논문

目的：了解深圳市宝安区流动人口肺结核患者的耐多药情况，为耐多药结核控制策略的制定提供参考和依据。方法收集可疑耐多药肺结核患者信息，并对其中痰培养阳性的患者进行菌种鉴定和药物敏感性检测。不同特征患者耐药情况的比较采用χ2检验或Fisher’s精确检验，显著性水平为0．05。结果2012年1－12月深圳市宝安区共筛查流动人口可疑耐多药肺结核患者984例，其中痰培养阳性756例（占87．02％）；经菌种鉴定，感染结核分枝杆菌的患者有740例。740例结核分枝杆菌感染的患者中，耐多药肺结核26例（占3．51％），仅对IN H耐药的有27例（占6．65％），仅对RFP耐药的有15例（占2．03％）。复发或治疗失败患者的耐药和耐多药率均显著高于新患者（P耐多药＜0．0001），有空洞的肺结核患者的耐药和耐多药率高于无空洞患者（χ2耐多药＝6．3268，P＝0．0119），不同性别（χ2耐多药＝0．2331，P＝0．6292）和年龄组患者（ P耐多药＝0．6644）的耐药和耐多药率差异均无统计学意义。结论深圳市宝安区流动人口肺结核患者耐多药检出率较低，应继续贯彻流动人口结核病患者管理策略，防止耐多药肺结核的产生和传播。
목적：료해심수시보안구류동인구폐결핵환자적내다약정황，위내다약결핵공제책략적제정제공삼고화의거。방법수집가의내다약폐결핵환자신식，병대기중담배양양성적환자진행균충감정화약물민감성검측。불동특정환자내약정황적비교채용χ2검험혹Fisher’s정학검험，현저성수평위0．05。결과2012년1－12월심수시보안구공사사류동인구가의내다약폐결핵환자984례，기중담배양양성756례（점87．02％）；경균충감정，감염결핵분지간균적환자유740례。740례결핵분지간균감염적환자중，내다약폐결핵26례（점3．51％），부대IN H내약적유27례（점6．65％），부대RFP내약적유15례（점2．03％）。복발혹치료실패환자적내약화내다약솔균현저고우신환자（P내다약＜0．0001），유공동적폐결핵환자적내약화내다약솔고우무공동환자（χ2내다약＝6．3268，P＝0．0119），불동성별（χ2내다약＝0．2331，P＝0．6292）화년령조환자（ P내다약＝0．6644）적내약화내다약솔차이균무통계학의의。결론심수시보안구류동인구폐결핵환자내다약검출솔교저，응계속관철류동인구결핵병환자관리책략，방지내다약폐결핵적산생화전파。
Objectives To learn the multi‐drug resistant tuberculosis (MDR‐TB) distribution among migrant pop‐ulation in Bao'an District ,Shenzhen .Methods Collecting information for suspicious of MDR‐TB patients and mak‐ing bacteria identification and drug susceptibility testing for patients with sputum culture positive .Chi‐square test or Fisher's exact test were used for comparing different characteristics of patients with MDR‐TB ,and the significance level was 0 .05 .Results There were 984 suspicious MDR‐TB patients in migrant population from January 2012 to December 2012 in Bao'an District ,Shenzhen ,of which 756 patients (87 .02% ) were sputum culture positive .Bacteria identifi‐cation was made further ,and 740 patients were infected with mycobacterium tuberculosis (Mtb) .Of the 740 patients with Mtb ,26 patients (3 .51% ) were MDR‐TB ,27 (6 .65% ) were only INH resistance TB ,15 (2 .03% )were RFP resistant only . The multi‐drug resistant rate was significant higher in recurrence or treatment failure patients than that in new patients (P<0.000 1) ,and was also higher in TB patients with cavity than that without cavity (χ2 =6 .326 8 ,P=0 .011 9) .There were no significant difference in multi‐drug resistant rate among different sex (χ2 = 0 .233 1 ,P= 0 .629 2 ) and age groups ( P=0 .664 4) .Conclusions Multi‐drug resistant rate was low among migrant population in Bao'an District ,Shenzhen .In order to prevent the generation and dissemination of MDR‐TB ,TB management strategy for migrant population should be continued .