CAJ | 학술논문

目的：探讨补肾益气养血方治疗复发性不明原因胚胎停育的临床疗效及其作用机制。方法选取82例复发性不明原因胚胎停育患者，根据患者意愿分为2组各41例，对照组给予孕酮、绒毛膜促性腺激素保胎治疗，治疗组给予口服补肾益气养血方3个疗程后自然受孕，妊娠后给予孕酮、绒毛膜促性腺激素保胎治疗，达前次妊娠相同孕周采血，测定血管内皮生长因子水平；当孕龄高于前次孕周2周以上记为妊娠成功，比较2组妊娠成功率。结果治疗组血清VEGF水平明显高于对照组（P＜0．05）；对照组成功率58％，治疗组成功率88％，治疗组高于对照组（P＜0．01）。结论补肾益气养血方联合传统西药保胎治疗不明原因胚胎停育疗效显著，其作用机制与上调血清中VEGF含量、改善生殖器官血液供应有关。
목적：탐토보신익기양혈방치료복발성불명원인배태정육적림상료효급기작용궤제。방법선취82례복발성불명원인배태정육환자，근거환자의원분위2조각41례，대조조급여잉동、융모막촉성선격소보태치료，치료조급여구복보신익기양혈방3개료정후자연수잉，임신후급여잉동、융모막촉성선격소보태치료，체전차임신상동잉주채혈，측정혈관내피생장인자수평；당잉령고우전차잉주2주이상기위임신성공，비교2조임신성공솔。결과치료조혈청VEGF수평명현고우대조조（P＜0．05）；대조조성공솔58％，치료조성공솔88％，치료조고우대조조（P＜0．01）。결론보신익기양혈방연합전통서약보태치료불명원인배태정육료효현저，기작용궤제여상조혈청중VEGF함량、개선생식기관혈액공응유관。
Objective It is to investigate the clinical effect of Bushen Yiqi Yangxue recipe on recurrent obscure embryo growth arrest and it ’ s mechanism.Methods According to their wishes , 82 recurrent obscure embryo growth arrest patients were divided them into two groups:treatment group and control group , each group had 41 cases.The control group was treated with progesterone and chorionic gonadotropin ,the treatment group was treated with Bushen Yiqi Yangxue recipe for 3 treatment courses before pregnancy again and treated as the control group after pregnancy .Their blood was gotten to determine the level of VEGF at the same gestational age as last time .When their gestational age passed last time for two weeks ,we considered it as successful pregnancy .After that , the success rate of pregnancy of the two groups was compared .Results The level of VEGF in the treatment group was significantly higher than that of the control group (P<0.05).The successful pregnancy rate was 58%in control group , which was significantly lower than that of 88% in treatment group ( P<0.01 ) .Conclusion The abortion prevention with Bushen Yiqi Yangxue recipe associated with traditional western medicine has a significant curative effect on ob -scure embryo growth arrest .The mechanism may be related with up -regulation the level of VEGF and improving the blood supplies of reproductive system .