CAJ | 학술논문

目的：观察瑞格列奈联合二甲双胍治疗初发2型肥胖型糖尿病的临床疗效。方法选取96例肥胖2型糖尿病患者随机分为两组，对照组48例采用二甲双胍治疗，观察组48例在对照组基础上采用瑞格列奈治疗，比较观察两组的血糖、血脂水平和体质量指数（BMI）的变化。结果两组治疗后FPG、2hPG水平均明显下降（P＜0.05）；并且，观察组治疗后FPG、2hPG水平均低于同期对照组水平（P＜0.05）。与治疗前比较，观察组治疗后VLDL、TG及BMI水平明显下降（P＜0.05），而对照组无明显差异（P＞0.05）。并且，观察组治疗后VLDL、TG及BMI水平均明显低于同期对照组（P＜0.05）。结论瑞格列奈联合二甲双胍初发2型肥胖型糖尿病进行治疗，降糖效果显著，并且能够明显降低患者血脂水平，值得临床推广应用。
목적：관찰서격렬내연합이갑쌍고치료초발2형비반형당뇨병적림상료효。방법선취96례비반2형당뇨병환자수궤분위량조，대조조48례채용이갑쌍고치료，관찰조48례재대조조기출상채용서격렬내치료，비교관찰량조적혈당、혈지수평화체질량지수（BMI）적변화。결과량조치료후FPG、2hPG수평균명현하강（P＜0.05）；병차，관찰조치료후FPG、2hPG수평균저우동기대조조수평（P＜0.05）。여치료전비교，관찰조치료후VLDL、TG급BMI수평명현하강（P＜0.05），이대조조무명현차이（P＞0.05）。병차，관찰조치료후VLDL、TG급BMI수평균명현저우동기대조조（P＜0.05）。결론서격렬내연합이갑쌍고초발2형비반형당뇨병진행치료，강당효과현저，병차능구명현강저환자혈지수평，치득림상추엄응용。
ObjectiveTo observe the clinical effect of repaglinide combined with metformin in treatment with obesity type 2 diabetes.Method 96 cases of obesity type 2 diabetes patients were classified into two groups,which control group of 48 cases were treated with metformin and observation group of 48 cases were treated with repaglinide at the base of control group. The levels of blood sugar,blood fat and body mass index (BMI)between the two groups were compared.Results Compared with pre-treatment, the FPG, 2hPGwere significantly increased(P<0.05)in both two groups after treatment. Moreover,the levels of FPG, 2hPG in observation group were significantly lower than those in control group(P<0.05).After treatment, the levels of VLDL,TG and BMI were significantly decreased,while no significant difference in control group(P>0.05). Moreover, the levels of VLDL, TG and BMI in observation group were significantly lower than those in control group(P<0.05).Conclusion Repaglinide combined with metformin in treatment with obesity type 2 diabetes can decrease blood sugar and blood fat,which can be applied in clinic.