CAJ | 학술논문

目的：评价经支气管动脉灌注化疗栓塞术（bronchial arterial chemoembolization，BACE）治疗中晚期肺癌患者后的远期疗效。方法回顾性分析经病理确诊、年龄在39~82岁的原发性肺癌或转移性肺癌患者168例，其中男性106例，女性62例，平均年龄67.6岁，鳞癌101例；腺癌41例；小细胞癌及小细胞伴肺内转移13例；混合性癌4例，转移性肺癌9例，均采用Seldinger技术，一般行右股动脉穿刺插管，运用4FCobra导管行支气管动脉造影后行支气管动脉灌注化疗栓塞，造影后予以敏感化疗药物灌注化疗，予聚乙烯醇颗粒、明胶海绵栓塞，3年内随访患者，根据其主观疗效、生存率及生活质量等情况评价其远期疗效。结果①随访168例不同病理组织细胞类型、不同病理分期的患者于术后反复复查胸部CT、生活质量及3年生存率等均明显不同，表明支气管动脉灌注化疗栓塞术治疗中晚期肺癌的必要性及可行性。②术后3年期间，随访168例肺癌患者目前135例患者已死亡，33例患者仍存活，部分患者出现疼痛症状。结论支气管动脉灌注化疗栓塞术治疗肺癌根据既往文献及本科室研究观察，近期疗效已较为显著。随着我科室对此类患者的随访，初步考虑BACE治疗肺癌患者可以提高患者生存质量及生存时间。
목적：평개경지기관동맥관주화료전새술（bronchial arterial chemoembolization，BACE）치료중만기폐암환자후적원기료효。방법회고성분석경병리학진、년령재39~82세적원발성폐암혹전이성폐암환자168례，기중남성106례，녀성62례，평균년령67.6세，린암101례；선암41례；소세포암급소세포반폐내전이13례；혼합성암4례，전이성폐암9례，균채용Seldinger기술，일반행우고동맥천자삽관，운용4FCobra도관행지기관동맥조영후행지기관동맥관주화료전새，조영후여이민감화료약물관주화료，여취을희순과립、명효해면전새，3년내수방환자，근거기주관료효、생존솔급생활질량등정황평개기원기료효。결과①수방168례불동병리조직세포류형、불동병리분기적환자우술후반복복사흉부CT、생활질량급3년생존솔등균명현불동，표명지기관동맥관주화료전새술치료중만기폐암적필요성급가행성。②술후3년기간，수방168례폐암환자목전135례환자이사망，33례환자잉존활，부분환자출현동통증상。결론지기관동맥관주화료전새술치료폐암근거기왕문헌급본과실연구관찰，근기료효이교위현저。수착아과실대차류환자적수방，초보고필BACE치료폐암환자가이제고환자생존질량급생존시간。
Objective To evaluate the bronchial arterial chemoembolization (BACE) long-term efficacy in the treatment of patients with advanced lung cancer.Methods A retrospective analysis of pathologically confirmed, aged 39-82 years old with primary lung cancer or metastatic lung cancer patients 168 cases, 106 cases were male, 62 female , mean age 67.6 years old(squamous cell carcinoma, adenocarcinoma, small cell carcinoma and small cell lung metastasis, mixed carcinoma, metastatic lung cancer, 101, 41, 13, 4, 9 respective) are using the Seldinger technique,the right femoral artery catheterization, use 4F Cobra underwent bronchial arteriography bronchial artery chemoembolization, after using angiography, polyvinyl alcohol particles , gelatin sponge embolization, based on subjective response, survival and quality of life , etc. Evaluate its long-term effect.Results First, followed up 168 cases of different types of pathological cells, in patients with different pathological stage after repeated review of chest CT, quality of life and 3-year survival was significantly different, indicating that bronchial arterial chemoembolization treatment of advanced lung cancer necessity and feasibility. Second,after 3 years of follow-up 168 cases of lung cancer patients currently have 135 patients died, 33 patients are still alive , some patients pain.Conclusion Bronchial artery chemoembolization treatment of lung cancer based on previous literature and research in our laboratory observation, short-term effect has been more significant. As my department for folloe-up of these patients, preliminary consideration of BACE treatment of lung cancer patients can improve patient quality of life and survival time.