重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2014年
28期
3718-3721
,共4页
B细胞,淋巴瘤%造血干细胞移植%利妥昔单抗
B細胞,淋巴瘤%造血榦細胞移植%利妥昔單抗
B세포,림파류%조혈간세포이식%리타석단항
B-cell,lymphoma%hematopoietic stem cell transplantation%rituximab
目的:探讨利妥昔单抗联合自体外周血造血干细胞移植(APBSCT)治疗 B细胞性非霍奇金淋巴瘤的疗效。方法回顾分析该院2007年1月至2013年10月44例确诊为侵袭性或复发难治性 B细胞淋巴瘤并接受 APBSCT治疗的患者临床资料。分为两组,治疗组(n=22):APBSCT前应用利妥昔单抗联合化疗或动员造血干细胞(2.9±1.1)次,移植后有条件患者采用利妥昔单抗加白细胞介素-2(IL-2)维持治疗;对照组(n=22):除未使用利妥昔单抗,其余处理与治疗组相同。结果治疗组和对照组采集单核细胞数分别为(13.01±4.22)×108/kg和(11.63±2.95)×108/kg(P=0.214)。两组均顺利完成造血重建。两组中性粒细胞恢复时间和血小板恢复时间差异无统计学意义(P>0.05)。移植后两组病例均达到完全缓解(CR),中位随访时间20(2~73)个月,治疗组2例复发,对照组5例复发。治疗组和对照组2年总生存率分别为95.0%和75.1%,差异无统计学意义(P=0.179),2年疾病无进展生存率分别为82.4%和74.5%,差异无统计学意义(P=0.393)。结论利妥昔单抗联合 APBSCT治疗侵袭性和(或)复发难治性B细胞非霍奇金淋巴瘤是可行的,但是否能使患者长期获益仍需要进一步研究。利妥昔单抗的加入不影响造血干细胞采集和造血重建。
目的:探討利妥昔單抗聯閤自體外週血造血榦細胞移植(APBSCT)治療 B細胞性非霍奇金淋巴瘤的療效。方法迴顧分析該院2007年1月至2013年10月44例確診為侵襲性或複髮難治性 B細胞淋巴瘤併接受 APBSCT治療的患者臨床資料。分為兩組,治療組(n=22):APBSCT前應用利妥昔單抗聯閤化療或動員造血榦細胞(2.9±1.1)次,移植後有條件患者採用利妥昔單抗加白細胞介素-2(IL-2)維持治療;對照組(n=22):除未使用利妥昔單抗,其餘處理與治療組相同。結果治療組和對照組採集單覈細胞數分彆為(13.01±4.22)×108/kg和(11.63±2.95)×108/kg(P=0.214)。兩組均順利完成造血重建。兩組中性粒細胞恢複時間和血小闆恢複時間差異無統計學意義(P>0.05)。移植後兩組病例均達到完全緩解(CR),中位隨訪時間20(2~73)箇月,治療組2例複髮,對照組5例複髮。治療組和對照組2年總生存率分彆為95.0%和75.1%,差異無統計學意義(P=0.179),2年疾病無進展生存率分彆為82.4%和74.5%,差異無統計學意義(P=0.393)。結論利妥昔單抗聯閤 APBSCT治療侵襲性和(或)複髮難治性B細胞非霍奇金淋巴瘤是可行的,但是否能使患者長期穫益仍需要進一步研究。利妥昔單抗的加入不影響造血榦細胞採集和造血重建。
목적:탐토리타석단항연합자체외주혈조혈간세포이식(APBSCT)치료 B세포성비곽기금림파류적료효。방법회고분석해원2007년1월지2013년10월44례학진위침습성혹복발난치성 B세포림파류병접수 APBSCT치료적환자림상자료。분위량조,치료조(n=22):APBSCT전응용리타석단항연합화료혹동원조혈간세포(2.9±1.1)차,이식후유조건환자채용리타석단항가백세포개소-2(IL-2)유지치료;대조조(n=22):제미사용리타석단항,기여처리여치료조상동。결과치료조화대조조채집단핵세포수분별위(13.01±4.22)×108/kg화(11.63±2.95)×108/kg(P=0.214)。량조균순리완성조혈중건。량조중성립세포회복시간화혈소판회복시간차이무통계학의의(P>0.05)。이식후량조병례균체도완전완해(CR),중위수방시간20(2~73)개월,치료조2례복발,대조조5례복발。치료조화대조조2년총생존솔분별위95.0%화75.1%,차이무통계학의의(P=0.179),2년질병무진전생존솔분별위82.4%화74.5%,차이무통계학의의(P=0.393)。결론리타석단항연합 APBSCT치료침습성화(혹)복발난치성B세포비곽기금림파류시가행적,단시부능사환자장기획익잉수요진일보연구。리타석단항적가입불영향조혈간세포채집화조혈중건。
Objective To evaluate the therapeutic effect of rituximab combined with autologous peripheral blood stem cell trans-plantation(APBSCT)in treatment of aggressive or refractory and recrrent B-cell non-Hodgkin′s lymphoma.Methods Forty-four patients with aggressive or refractory and recrrent B-cell non-Hodgkin′s lymphoma and treated with APBSCT in this department from Janauary 2007 to October 2013 were admitted.All the subjects were divided into 2 groups according to their own choice:22 pa-tients received rituximab treatment(treatment group)and 22 patients were treated without rituximab treatment(control group).For patients in treatment group,rituximab was used with chemotherapy or mobilization of stem cells before APBSCT for (2.9±1.1) times.After transplantation,IL-2 was used in both groups as maintenance treatment.And rituximab was used in the treatment group if the budget allows.Results The mononuclear cell count in treatment and control group was (13.01±4.22)×108/kg and (11.63±2.95)×108/kg(P=0.214).Hematopoietic reconstruction was successfully achieved in the both groups.No significant difference was found between 2 groups on the recovery time of neutrophilic granulocytes and platelets(P>0.05).All patients a-chieved complete remission(CR),at a median follow-up of 20 months(2-73 months),the disease relapsed in 2 patients in treatment group and 5 in control group.The 2-year overall survival rate in treatment group and control group were 95.0% and 75.1%,2-year progression-free survival rates were 82.4% and 74.5%,there were no significant difference between two groups(P=0.179, 0.393).Conclusion Rituximab combined with APBSCT in treatment of aggressive or refractory and recurrent B-cell lymphoma is feasible,however whether patients can benefit from long-term studies still need further research.Adding rituximab does not affect the hematopoietic stem cell collection and hematopoietic reconstitution.