中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2014年
29期
31-34
,共4页
七氟烷%丙泊酚%术后认知功能障碍%S100茁蛋白
七氟烷%丙泊酚%術後認知功能障礙%S100茁蛋白
칠불완%병박분%술후인지공능장애%S100촬단백
Sevoflurane%Propofol%Postoperative cognitive dysfunction%S100βprotein
目的：研究七氟烷与丙泊酚用于老年腹部手术患者全身麻醉对术后认知功能影响。方法将146例老年腹部手术患者随机分为A组和B组，每组73例，分别采用七氟烷和丙泊酚进行麻醉维持。结果 A组苏醒时间、拔管时间均显著少于B组(P<0.05)。 A组和B组术后2 h、6 h、12 h MMSE均显著低于术前(P<0.05)，术后24 h、48 h认知状态恢复正常，B组术后2 h、6 h、12 h MMSE显著高于A组(P<0.05)。 A组和B组术前、术后2 h、术后24 h血清S100β蛋白、IL-2水平术后2 h均较术前显著升高(P<0.05)，术后24 h则回落，B组术后2 h血清S100β蛋白、IL-2水平显著低于A组(P<0.05)。结论七氟烷与丙泊酚用于老年腹部手术患者全身麻醉均可引起不同程度可逆性术后认知功能障碍，均可较快恢复，七氟烷引起的认知功能障碍程度较重，术后认知功能障碍与血清S100β蛋白、IL-2升高相关。
目的：研究七氟烷與丙泊酚用于老年腹部手術患者全身痳醉對術後認知功能影響。方法將146例老年腹部手術患者隨機分為A組和B組，每組73例，分彆採用七氟烷和丙泊酚進行痳醉維持。結果 A組囌醒時間、拔管時間均顯著少于B組(P<0.05)。 A組和B組術後2 h、6 h、12 h MMSE均顯著低于術前(P<0.05)，術後24 h、48 h認知狀態恢複正常，B組術後2 h、6 h、12 h MMSE顯著高于A組(P<0.05)。 A組和B組術前、術後2 h、術後24 h血清S100β蛋白、IL-2水平術後2 h均較術前顯著升高(P<0.05)，術後24 h則迴落，B組術後2 h血清S100β蛋白、IL-2水平顯著低于A組(P<0.05)。結論七氟烷與丙泊酚用于老年腹部手術患者全身痳醉均可引起不同程度可逆性術後認知功能障礙，均可較快恢複，七氟烷引起的認知功能障礙程度較重，術後認知功能障礙與血清S100β蛋白、IL-2升高相關。
목적：연구칠불완여병박분용우노년복부수술환자전신마취대술후인지공능영향。방법장146례노년복부수술환자수궤분위A조화B조，매조73례，분별채용칠불완화병박분진행마취유지。결과 A조소성시간、발관시간균현저소우B조(P<0.05)。 A조화B조술후2 h、6 h、12 h MMSE균현저저우술전(P<0.05)，술후24 h、48 h인지상태회복정상，B조술후2 h、6 h、12 h MMSE현저고우A조(P<0.05)。 A조화B조술전、술후2 h、술후24 h혈청S100β단백、IL-2수평술후2 h균교술전현저승고(P<0.05)，술후24 h칙회락，B조술후2 h혈청S100β단백、IL-2수평현저저우A조(P<0.05)。결론칠불완여병박분용우노년복부수술환자전신마취균가인기불동정도가역성술후인지공능장애，균가교쾌회복，칠불완인기적인지공능장애정도교중，술후인지공능장애여혈청S100β단백、IL-2승고상관。
Objective To study sevoflurane and propofol for abdominal surgery in elderly patients with general anesthe-sia on postoperative cognitive function. Methods A total of 146 elderly patients with abdominal surgery were randomly divided into group A and group B, each of 73 cases, respectively, used sevoflurane and propofol anesthesia maintained. Results Set of recovery time, extubation time in group A were significantly less than group B (P<0.05). Group A and group B after 2 h, 6 h, 12 h MMSE were significantly lower than the preoperative (P<0.05), after 24 h, 48 h normal cognitive status, after 2 h, 6 h, 12 h MMSE in group B were significantly higher than those in group A(P<0.05). A group and B group before and after surgery 2 h, 24 h after serum S100βprotein, IL-2 levels after 2h before surgery were sig-nificantly higher than preoperative (P<0.05), 24 h after the fall, group B after 2 h serum S100β protein, IL-2 levels were significantly lower than group A (P<0.05). Conclusion Sevoflurane and propofol for abdominal surgery under general anesthesia in elderly patients with varying degrees of reversibility may cause postoperative cognitive dysfunc-tion, can be quickly restored, the degree of dysfunction induced by sevoflurane cognitive heavier, postoperative cogni-tive dysfunction and serum S100βprotein, IL-2 increases related.
