CAJ | 학술논문

目的：探讨难治性幻听患者应用rTMS治疗后幻听评分及血清BDNF水平的变化及意义。方法选择2011~2013年我院共收治50例难治性幻听患者，依据随机数字表法将患者分为观察组和对照组两组，每组25例。对照组患者采用假性rTMS刺激治疗，观察组患者采用真性rTMS刺激治疗，对两组患者的幻听评分、血清BDNF水平进行统计学分析。结果治疗后观察组患者的幻听评分明显比对照组低(P<0.05)；治疗后2、4周观察组患者的血清BDNF水平均明显比对照组高(P<0.05)。结论难治性幻听患者应用真性rTMS刺激治疗较假性rTMS刺激治疗更能有效提升患者的BDNF水平，从而极大改善患者的幻听。
목적：탐토난치성환은환자응용rTMS치료후환은평분급혈청BDNF수평적변화급의의。방법선택2011~2013년아원공수치50례난치성환은환자，의거수궤수자표법장환자분위관찰조화대조조량조，매조25례。대조조환자채용가성rTMS자격치료，관찰조환자채용진성rTMS자격치료，대량조환자적환은평분、혈청BDNF수평진행통계학분석。결과치료후관찰조환자적환은평분명현비대조조저(P<0.05)；치료후2、4주관찰조환자적혈청BDNF수평균명현비대조조고(P<0.05)。결론난치성환은환자응용진성rTMS자격치료교가성rTMS자격치료경능유효제승환자적BDNF수평，종이겁대개선환자적환은。
Objective To investigate the changes and significance of auditory hallucinations score and serum BDNF levels of refractory auditory hallucinations patients after rTMS therapy. Methods Fifty cases of patients with refractory auditory hallucinations who were treated in our hospital from 2011 to 2013 were selected. These patients were divided into observation group and control group according to a random number table, 25 cases in each group. The patients in control group were given pseudo-rTMS stimulation therapy, while the observation group were given true rTMS stimula-tion therapy, then the auditory hallucinations score, serum BDNF levels of the two groups of patients were analyzed. Results After treatment, the auditory hallucinations score of the observation group was significantly lower (P<0.05); the serum BDNF levels after 2,4 weeks treatment of the observation group were significantly higher than those of the control group (P<0.05). Conclusion True rTMS stimulation therapy is more effective to enhance patient's BDNF lev-els, thereby greatly improve the auditory hallucinations than pseudo-rTMS stimulation therapy in the treatment of re-fractory auditory hallucinations patients.