中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2014年
29期
21-23
,共3页
胰岛素增敏剂%二甲双孤片%吡格列酮%达英-35%多囊卵巢
胰島素增敏劑%二甲雙孤片%吡格列酮%達英-35%多囊卵巢
이도소증민제%이갑쌍고편%필격렬동%체영-35%다낭란소
Insulin sensitizing agent%Two armor double solitary%Pioglitazone%Diane-35%Polycystic ovary
目的：探讨胰岛素增敏剂联合达英-35治疗多囊卵巢综合征(孕悦韵杂)临床疗效。方法100例PCOS随机分为对照组与观察组，每组50例。对照组单独采用达英-35进行治疗，观察组在此基础上采用胰岛素增敏剂进行治疗。比较两组临床疗效、性激素变化水平、排卵率及妊娠率、不良反应等。结果①经治疗，观察组临床总有效率为86.00%，对照组临床总有效率为66.00%，两组临床疗效比较差异具有统计学意义(P<0.05)；②对照组治疗后FSH、LH、LF/FSH、催乳素、E2及T水平分别为(5.56±1.20)IU/L、(11.65±3.73)IU/L、(2.45±1.61)、(16.87±4.02)ng/L、(68.02±13.41)pg/L及(1.71±0.34)pg/L，观察组治疗后上述水平分别为(4.03±0.56)IU/L、(8.23±1.68)IU/L、(1.43±0.44)、(13.01±2.76)ng/L、(53.71±10.25)pg/L及(0.67±0.09)pg/L，两组比较，差异均具有统计学意义(P<0.05)；③对照组排卵率及妊娠率分别为54.00%及64.00%，均显著小于观察组(分别为80.00%及86.00%)，差异有统计学意义(P<0.05)；榆两组均未出现不良反应。结论胰岛素增敏剂联合达英-35治疗PCOS，疗效显著，安全性高，值得临床推广及应用。
目的：探討胰島素增敏劑聯閤達英-35治療多囊卵巢綜閤徵(孕悅韻雜)臨床療效。方法100例PCOS隨機分為對照組與觀察組，每組50例。對照組單獨採用達英-35進行治療，觀察組在此基礎上採用胰島素增敏劑進行治療。比較兩組臨床療效、性激素變化水平、排卵率及妊娠率、不良反應等。結果①經治療，觀察組臨床總有效率為86.00%，對照組臨床總有效率為66.00%，兩組臨床療效比較差異具有統計學意義(P<0.05)；②對照組治療後FSH、LH、LF/FSH、催乳素、E2及T水平分彆為(5.56±1.20)IU/L、(11.65±3.73)IU/L、(2.45±1.61)、(16.87±4.02)ng/L、(68.02±13.41)pg/L及(1.71±0.34)pg/L，觀察組治療後上述水平分彆為(4.03±0.56)IU/L、(8.23±1.68)IU/L、(1.43±0.44)、(13.01±2.76)ng/L、(53.71±10.25)pg/L及(0.67±0.09)pg/L，兩組比較，差異均具有統計學意義(P<0.05)；③對照組排卵率及妊娠率分彆為54.00%及64.00%，均顯著小于觀察組(分彆為80.00%及86.00%)，差異有統計學意義(P<0.05)；榆兩組均未齣現不良反應。結論胰島素增敏劑聯閤達英-35治療PCOS，療效顯著，安全性高，值得臨床推廣及應用。
목적：탐토이도소증민제연합체영-35치료다낭란소종합정(잉열운잡)림상료효。방법100례PCOS수궤분위대조조여관찰조，매조50례。대조조단독채용체영-35진행치료，관찰조재차기출상채용이도소증민제진행치료。비교량조림상료효、성격소변화수평、배란솔급임신솔、불량반응등。결과①경치료，관찰조림상총유효솔위86.00%，대조조림상총유효솔위66.00%，량조림상료효비교차이구유통계학의의(P<0.05)；②대조조치료후FSH、LH、LF/FSH、최유소、E2급T수평분별위(5.56±1.20)IU/L、(11.65±3.73)IU/L、(2.45±1.61)、(16.87±4.02)ng/L、(68.02±13.41)pg/L급(1.71±0.34)pg/L，관찰조치료후상술수평분별위(4.03±0.56)IU/L、(8.23±1.68)IU/L、(1.43±0.44)、(13.01±2.76)ng/L、(53.71±10.25)pg/L급(0.67±0.09)pg/L，량조비교，차이균구유통계학의의(P<0.05)；③대조조배란솔급임신솔분별위54.00%급64.00%，균현저소우관찰조(분별위80.00%급86.00%)，차이유통계학의의(P<0.05)；유량조균미출현불량반응。결론이도소증민제연합체영-35치료PCOS，료효현저，안전성고，치득림상추엄급응용。
Objective To explore the effect of insulin sensitizer combined with Diane-35 in the treatment of polycys-tic ovary syndrome (PCOS). Methods A total of 100 cases of PCOS patients were randomly divided into control group and observation group, 50 cases in each group. The control group was treated by with Diane-35 treatment, the observa-tion group based on the use of insulin sensitizing agent. the curative effect, sex hormone levels, the ovulation rate and pregnancy rate, the incidence of adverse reactions were compared between two groups. Results (1) After the treatment, the total clinical effective rate of observation group was 86.00%, was higher than the control group (66.00%),the differ ence was significant(P<0.05); (2) After treatment, FSH, LH, LF/FSH, prolactin, E2 and T levels of the control group were (5.56±1.20) IU/L, (11.65±3.73) IU/L, (2.45±1.61), (16.87±4.02) ng/L, (68.02±13.41) pg/L and (1.71±0.34) pg/L, the levels of the observation group were (4.03±0.56) IU/L, (8.23±1.68) IU/L, (1.43±0.44), (13.01±2.76) ng/L, (53.71±10.25) pg/L and (0.67±0.09) pg/L, differences in hormone levels between the two groups were statistically significant (P<0.05); (3) The ovulation rate and pregnancy rate of control group was 54.00% and 64.00%, significantly less than the observation group (respectively were 80.00% and 86.00%), the differences were statistically significant (P<0.05); (4) There was no adverse reaction happened in two groups. Conclusion Insulin sensitizer combined with Diane-35 in treatment of PCOS has good curative effect, high safety, and is worth to promote and clinical application.
